| 蝎毒耐热蛋白对外源性Aβ活化星形胶质细胞的作用 |
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| 引用本文： | 于胜波,宫瑾,隋鸿锦,高海斌,彭岩,赵杰,张万琴.蝎毒耐热蛋白对外源性Aβ活化星形胶质细胞的作用[J].解剖科学进展,2008,14(1):54-55,57. |
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| 作者姓名： | 于胜波 宫瑾 隋鸿锦 高海斌 彭岩 赵杰 张万琴 |
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| 作者单位： | 1. 大连医科大学解剖学教研室,辽宁,大连,116044
2. 大连医科大学生理学教研室,辽宁,大连,116044 |
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| 基金项目： | 国家自然科学基金(No．30770737) |
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| 摘 要： | 目的观察蝎毒耐热蛋白(SVHRP)对Aβ_(1-40)活化星形胶质细胞(AST)作用的影响。方法应用Aβ_(1-40)进行大鼠海马内定位注射后腹腔给予SVHRP进行干预,16d后应用免疫组化法进行海马内GFAP免疫反应强度检测。结果Aβ_(1-40)注射点周围GFAP免疫反应明显增强,而经SVHRP干预后GFAP免疫反应显著减弱,接近正常对照水平。结论腹腔注射SVHRP可抑制外源性Aβ_(1-40)引起的大鼠海马内AST活化。
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| 关 键 词： | 淀粉样β蛋白 蝎毒耐热蛋白 胶质原纤维酸性蛋白 |
| 文章编号： | 1006-2947（2008）01-0054-02 |
| 收稿时间： | 2007-11-06 |
| 修稿时间： | 2007年11月6日 |
Effect of SVHRP on the Activation of Astrocytes by A β1-40 in Hippocampus of Rat |
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| YU Sheng-Bo,GONG Jin,SUI Hong-Jin,GAO Hai-Bin,PENG Yan,ZHAO Jie,ZHANG Wan-qian.Effect of SVHRP on the Activation of Astrocytes by A β1-40 in Hippocampus of Rat[J].Progress of Anatomical Sciences,2008,14(1):54-55,57. |
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| Authors: | YU Sheng-Bo GONG Jin SUI Hong-Jin GAO Hai-Bin PENG Yan ZHAO Jie ZHANG Wan-qian |
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| Abstract: | Objective To study the effect of scorpion venom heat-resistant protein(SVHRP)on the activation of astrocytes(AST)by Aβ_(1-40).Methods Aβ_(1-40)was injectel into hippocampus and SVHRP was applied through intraperitoneal injection in rats.16 days after injection,immunohistochemistry was used.Results The number of GFAP-positive AST around the Aβ_(1-40),injected point increased significantly in Aβ_(1-40)injection group than in normal control group,but decreased after SVHRP administration compared to Aβ_(1-40)injection group.Conclusions SVHRP can markedly inhibit the activation of AST by Aβ_(1-40). |
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| Keywords: | amyloid beta protein scorpion Venom heat-resistant protein glial fibrillary acidic protein |
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