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| 聚集素在前列腺正常、增生、癌组织中的表达及意义 | |
| 引用本文： | Zhou LQ,Yang XZ,Zeng L,Liang LL,Yang XY,Ren L,Chung L,Zhang ZW,Na YQ,Gu FL,Guo YL. 聚集素在前列腺正常、增生、癌组织中的表达及意义[J]. 中华外科杂志, 2003, 41(2): 93-95 |
| 作者姓名： | Zhou LQ Yang XZ Zeng L Liang LL Yang XY Ren L Chung L Zhang ZW Na YQ Gu FL Guo YL |
| 作者单位： | 1. 100034,北京大学第一医院泌尿外科研究所 2. Department of Urology, Northwestern University Medical School,Chicago,USA 3. 北京大学生理学系 |
| 基金项目： | 国家自然科学基金资助项目 (3980 0 173),国家教委留学归国人员科研启动基金资助项目 (1998 2 0 0 0 ) |
| 摘 要： | 目的 通过检测聚集素 (Clusterin)在前列腺正常、增生、癌变组织中的表达 ,探讨其与前列腺疾病发生发展的关系。 方法 采用免疫组织化学染色法检测 12例正常前列腺组织、15例良性前列腺增生组织 (BPH)、5 6例前列腺癌标本中Clusterin的表达水平。 结果 3种组织中Clusterin的阳性及弱阳性表达率为 81% (67/83 ) ,其中前列腺正常、增生、癌组织中阳性及弱阳性表达率分别为17% (2 /12 )、73 % (11/15 )、96% (5 4/5 6)。前列腺癌组织中Clusterin表达水平明显高于前列腺正常 (t=8 82 ,P <0 0 1)及增生 (t =7 63 ,P <0 0 1)组织 ,且在癌组织中与肿瘤病理分级 (r =0 64 9,P <0 0 1)、临床分期 (r=0 60 9,P <0 0 1)呈正相关。 结论 Clusterin可能通过抗凋亡机制在前列腺癌的生物特性中发挥着重要的作用 |
| 关 键 词： | 前列腺肿瘤 脱噬作用 癌 Clusterin 免疫组织化学 |
| 修稿时间： | 2002-02-27 |
Expression and significance of clusterin in normal prostate,benign prostate hyperplasia and prostate cancer |
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| Zhou Li-qun,Yang Xue-zhen,Zeng Li,Liang Li-li,Yang Xin-yu,Ren Liang,Chung Lee,Zhang Zhi-wen,Na Yan-qun,Gu Fang-liu,Guo Ying-lu. Expression and significance of clusterin in normal prostate,benign prostate hyperplasia and prostate cancer[J]. Chinese Journal of Surgery, 2003, 41(2): 93-95 | |
| Authors: | Zhou Li-qun Yang Xue-zhen Zeng Li Liang Li-li Yang Xin-yu Ren Liang Chung Lee Zhang Zhi-wen Na Yan-qun Gu Fang-liu Guo Ying-lu |
| Affiliation: | Institute of Urology, First Hospital, Peking University, Beijing 100034, China. |
| Abstract: | OBJECTIVE: To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer. METHODS: Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain. RESULTS: Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer. CONCLUSION: Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway. |
| Keywords: | Prostatic neoplasms Apoptosis Carcinoma Clusterin Immunohistochemstrg |
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