| 血管内皮细胞生长因子在颊癌中的表达及意义 |
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| 引用本文： | 韩诚敏,徐雅娟,刘文书,那辉.血管内皮细胞生长因子在颊癌中的表达及意义[J].吉林大学学报(医学版),2006,32(4):651-653. |
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| 作者姓名： | 韩诚敏 徐雅娟 刘文书 那辉 |
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| 作者单位： | 1. 吉林大学口腔医院颌面外科，吉林 长春130041；2. 吉林省肿瘤医院头颈外科，吉林 长春130012；3. 吉林大学第一医院口腔科，吉林 长春130021；4. 吉林大学化学院高分子科学系，吉林 长春130012 |
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| 基金项目： | 国防科工委民口配套研制项目 |
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| 摘 要： | 目的：研究血管内皮细胞生长因子在颊癌中的表达，探讨其与颊癌的发生、发展的关系。
方法：采用免疫组织化学S-P法检测40例颊癌组织、30例癌旁组织、10例正常颊黏膜组织中血管内皮细胞生长因子（VEGF）表达水平的变化。
结果：颊癌组织、癌旁组织和正常颊黏膜组织中的VEGF表达率分别为85.0%、26.7%、10.0%，经统计学处理三者表达率比较差异有显著性（χ2 =32.26，P<0.01）；随着病理分级的升高，VEGF阳性表达强度增高，与病理分级呈正相关(rs=0.672, P<0.001）；随着临床分期的升高，VEGF阳性强度增强，与临床分期呈正相关（rs=0.493, P<0.01）。
结论：VEGF在颊癌发生、发展、浸润及转移中具有重要的作用，可作为一种有价值的标志物。
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| 关 键 词： | 血管内皮细胞生长因子 颊鳞状细胞癌 免疫组织化学 |
| 文章编号： | 1671-587X(2006)04-0651-03 |
| 收稿时间： | 2005-12-30 |
| 修稿时间： | 2005年12月30日 |
Expression of vascular endothelial growth factor in carcinoma of cheek and its significance |
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| HAN Cheng-min,XU Ya-juan,LIU Wen-shu,NA Hui.Expression of vascular endothelial growth factor in carcinoma of cheek and its significance[J].Journal of Jilin University: Med Ed,2006,32(4):651-653. |
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| Authors: | HAN Cheng-min XU Ya-juan LIU Wen-shu NA Hui |
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| Institution: | 1. Department of Maxillofacial Surgery, Stomatology Hospital, Jilin University, Changchun 130041,China;2. Tumour Hospital of Jilin Province， Changchun 130012,China; 3. Department of Stomatology, First Hospital，Jilin University，Changchun 130021, China; 4. Department of MacromolecularSciences, School of Chemistry, Jilin University, Changchun 130012, China |
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| Abstract: | Objective To study the expression of vascular endothelial growth factor(VEGF) in carcinoma of cheek in order to investigate the relation with carcinogenesis and development of carcinoma of cheek.Methods The expression levels of VEGF were determined by S-P method of immunohistochemistry technique in 40 tissues of carcinoma of cheek,30 para-carcinoma and 10 normal mucosa.Results The expression rates of VEGF in the tissues of carcinoma of cheek,para-carcinoma and normal mucosa were 85.0%,26.7%,10.0%,respectively.There was remarkable difference in the statistic(χ~2=32.26,P<0.01).The VEGF expression level showed positive correlation with the pathologic grade of carcinoma of cheek(r_s=0.672,P<0.001) and clinic stage of carcinoma of cheek(r_s =0.493,P<0.01).Conclusion VEGF plays important roles in the development,infestation and transfer in carcinoma of cheek.It can be regarded as a valuable marker. |
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| Keywords: | facial neoplasms vascular endothelial growth factor squamous cell carcinoma of cheek immunohistochemistry |
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