Development of Immunosorbents for apoB-Containing Lipoproteins Apheresis |
| |
| Authors: | Sergei N Pokrovsky rey V Sussekov Irina Y Adamova Olga I Afanasieva Galina F Benevolenskaya Gennady A Konovalov Valery V Kukharchuk |
| |
| Institution: | Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia;Institute of Clinical Cardiology, Cardiology Research Center, Moscow, Russia |
| |
| Abstract: | Abstract: Three types of sorbents were developed for the specific removal of atherogenic apoB-containing low-density lipoprotein (LDL) and lipoprotein LDL(a) (Lpa])from human plasma. Two sorbents contained monospecific sheep polyclonal or mouse monoclonal antibodies against human apoprotein B-100. The third one was intended for specific removal of Lp(a) and contains sheep antibodies against human Lp(a). Thirty patients were treated for up to 9 years by LDL apheresis with anti-LDL immunosorbents. A pilot study of Lp(a) apheresis with 3 patients was conducted during 3 years. The results showed that extracorporeal immunosorption is safe and effective for lowering LDL and Lp(a). These procedures may be used both for metabolic investigations and for studies on possible regression of atherosclerosis. |
| |
| Keywords: | Apheresis Immunosorbents apoB-containing lipoproteins LDL Lp(a) LDL apheresis Lp(a) apheresis |
|
