舒通胶囊对慢传输型便秘大鼠大肠推进及胃肠激素影响

目的：观察舒通胶囊对慢传输型便秘（STC）大鼠大肠推进及胃肠激素作用。方法：使用大黄提取液灌胃制作大白鼠sTc，随机分为舒通胶囊低、中、高剂量组（0．54、1．08、2．16g·kg1-·d-1），模型组，麻仁丸组，观察舒通胶囊对STC模型大鼠首次排出黑粪时间，5、12h排出黑粪总粒数，大鼠体内血浆P物质（sP）、胃动素（MTL）、NO水平的变化。结果：治疗2周后，与STC模型组比较，舒通胶囊中、高剂量组明显缩短STC模型大鼠首次排出黑粪时间，增加5、12h排出黑粪总粒数（P〈0．05，P〈0．01）；舒通胶囊中、高剂量组对SP、NO、MTL水平的影响显著，差异有统计学意义（P〈0．05）。麻仁丸组与舒通胶囊高剂量组、中剂量组比较差异无统计学意义（P〉0．05）。结论：舒通胶囊能促进STC大鼠排便，使STC大鼠模型体内SP、MTL的水平升高，NO水平降低；其作用机制可能与调节胃肠激素水平有关。

Influence of Shutong Capsula on Defecating and Gastrointestinal Hormones of Siow Transit Constipation in Rats

Objective ： To study the efficacy of Shutong Capsules on promoting large intestine enterokinesia and gastrointestinal hormones of the slow transit constipation in rats. Methods ： Sixty Wistar rats were randomly divided into normal control group （ 10 rats ）and model group （ STC,50 rats ）. Fifty STC rats were divided into 5 groups： STC model group, Shutong Capsules low dosage, middle dosage and high dosage （ 0.54,1.08,2.16 g. kg-1 . d-1 ）groups, and Maren pills group. After 2-week treatment, the discharge time of the first black feces, the black feces＇s total number at 5 hours and 12 hours were observed. Levels of plasma substance P （ SP ）, nitric oxide （ NO ） and motilin （ MTL ） were determined. Results ： Shutong Capsules middle and high dose groups＇ rats shortened discharge time of the first black feces and increased black discharge points （P〈0.05, P〈0.01 ）. Shutong Capsules middle dosage and high dosage groups＇ plasma substance P （ SP ）, nitric oxide （ NO ） and motilin （ MTL ） contents difference were statistically significant （ P〈0.05 ）. Conclusion ： Shutong Capsules can obviously promote facilitation function to the STC rats colon, raise SP and MTL levels, and reduce NO level of STC, which is probably due to its regulation of the gastro intestinal hormones levels.