| Bcl-2、P53、CyclinD1在B细胞淋巴瘤中的表达及意义 |
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| 引用本文： | 吕晓涛,张继新,高颖,沈冰,曲从玲,张程燕,昌红,李保玉.Bcl-2、P53、CyclinD1在B细胞淋巴瘤中的表达及意义[J].山东医药,2010,50(40):25-27. |
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| 作者姓名： | 吕晓涛 张继新 高颖 沈冰 曲从玲 张程燕 昌红 李保玉 |
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| 作者单位： | 北京大学第九临床医学院北京世纪坛医院,北京,100038 |
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| 摘 要： | 目的探讨Bc l-2、P53和细胞周期蛋白D1（CyclinD1）在B细胞淋巴瘤发生发展中的作用。方法采用组织芯片技术制备高通量的样本,采用免疫组织化学SP法检测Bc l-2、P53、Cyc linD1在B细胞淋巴瘤中的表达。结果 Bc l-2和P53主要表达于弥漫性大B细胞淋巴瘤、滤泡性淋巴瘤、黏膜相关淋巴组织结外边缘淋巴瘤、套细胞淋巴瘤和小淋巴细胞淋巴瘤;而CyclinD1只在套细胞淋巴瘤和弥漫性大B细胞淋巴瘤中表达。结论由Bc l-2和P53协同表达途径以及CyclinD1异常表达途径是弥漫性大B细胞淋巴瘤发生的重要机制。
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| 关 键 词： | 淋巴瘤 B细胞 基因 bcl-2 基因 P53 细胞周期蛋白D1 |
Expression and clinical significance of Bcl-2, P53, CyclinD1 in B-cell lymphoma |
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| LV Xiao-tao,ZHANG Ji-xin,GAO Ying,SHEN Bing,QU Cong-ling,ZHANG Cheng-yan,CHANG Hong,LI Bao-yu.Expression and clinical significance of Bcl-2, P53, CyclinD1 in B-cell lymphoma[J].Shandong Medical Journal,2010,50(40):25-27. |
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| Authors: | LV Xiao-tao ZHANG Ji-xin GAO Ying SHEN Bing QU Cong-ling ZHANG Cheng-yan CHANG Hong LI Bao-yu |
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| Institution: | (The Ninth Clinical Medical College of Peking University,Beijing Shijitan Hospital,Beijing 100038,P.R.China) |
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| Abstract: | Objective To investigate the expression of Bcl-2,P53,CyclinD1 in B-cell lymphoma and their relevance with the development of B-cell lymphoma.Methods The preparation of high-throughput sample was made by method of tissue microarray.The expression of Bcl-2,P53,CyclinD1 in B-cell lymphoma was examined by using immunohistochemical staining.Results The expression of Bcl-2 and P53 was significantly higher in DLBCL,FL,MALT,MCL and SLL than that in normal tissues.CyclinD1 was only detected in DLBCL and MCL.Conclusions The coordination expression of Bcl-2 and P53 and the abnormal expression of CyclinD1 were two important mechanism of the occurrence of DLBCL. |
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| Keywords: | lymphoma B-cell genes bcl-2 genes p53 CyclinD1 |
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