Quantitative autoradiographic localization of D-1 dopamine receptors in the rat brain: use of the iodinated ligand [125I]SCH 23982 |
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| Authors: | T M Dawson P Barone A Sidhu J K Wamsley T N Chase |
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| Affiliation: | 1. Department of Buildings, Roads, and Space Engineering, Faculty of Engineering and Technology, Palestine Technical University -Kadoorie, Tulkarm, Palestine;2. Department of Transport Technology and Economics, Faculty of Transportation Engineering and Vehicle Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary |
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| Abstract: | In vitro autoradiography was used to visualize [125I]SCH 23982 binding sites in rat brain. Labeling was concentrated in the caudate-putamen, accumbens nucleus, olfactory tubercle, substantia nigra pars reticulata and the entopeduncular nucleus. [125I]SCH 23982 labels predominantly D-1 receptors but also labels 5-HT2 receptors in certain areas of the brain. These findings may relate to the distribution of dopamine's cerebral loci of action on D-1 receptors. |
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