Prediction of Creatinine Clearance from Serum Creatinine in Patients with Rheumatoid Arthritis: Comparison of Six Formulae and One Nomogram |
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Authors: | H-J. Anders M. Rihl O. Loch M. Schattenkirchner |
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Affiliation: | Medizinische Poliklinik, Ludwig-Maximilians Universit?t Munich, Germany, DE
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Abstract: | The estimation of glomerular filtration rate is important for the medical treatment of patients with rheumatoid arthritis (RA). However, the determination of endogenous creatinine clearance (Clcr) from a 24-h urine collection is an unreliable and time-consuming procedure. We therefore tested the accuracy of six equations and one nomogram for the prediction of Clcr from serum creatinine (Scr) in 38 patients with RA and 20 controls. A positive correlation was found for all methods in the controls (r= 0.83–0.94) and RA patients (r= 0.51–0.69). The methods did not overestimate Clcr in RA. In the RA group the simple formula published by Cockcroft [Clcr = ((140 − age) × body weight)/(72 × Scr), × 0.85 for females] showed the best correlation with the measured Clcr. In RA the Cockroft formula can reliably be used to predict Clcr from Scr. Received: 8 February 1999 / Accepted: 4 June 1999 |
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Keywords: | :Calculation – Creatinine clearance – Estimation – Muscle mass – Pharmacology – Prediction – Renal function – Rheumatoid arthritis – Wasting formula |
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