胃肠道癌患者生命质量影响因素初探

背景与目的:生命质量测评已广泛应用在肿瘤研究中,而癌症患者生命质量研究对于推动癌症治疗的进步也起着越来越重要的作用.本研究旨在评估胃癌、大肠癌患者的生命质量,探讨与之相关的影响因素.方法:自2005年2月1日至2006年8月31日,采用癌症患者生命质量测定量表核心量表EORTC QLQ C30调查了52例胃癌患者和50例大肠癌患者.各影响生命质量凶素的差异程度经t检验及方差分析处理.最优尺度回归分析和判别方程了解生命质量各个子量表与临床分期的关系.多重线性回归分析整体生命质量与功能量表、症状量表及单项量表的关系.结果:临床分期较早期、高文化程度、经过综合治疗后的患者显示较高的功能量表得分和整体生命质量得分,以及较低的症状量表及单项量表得分,因而生命质量较好.年龄、性别等对生命质量影响不大.胃癌组整体生命质量量表得分低于大肠癌组,提示胃癌患者相对于大肠癌患者生命质量较差.结论:临床分期、文化程度和治疗方法是影响胃肠道癌患者生命质量的最重要因素.

Factors affecting quality of life of patients with gastrointestinal cancer

BACKGROUND & OBJECTIVE: The evaluation of quality of life (QOL) has been used widely in cancer research, and the research of QOL for cancer patients makes more and more effect on the improvement of cancer treatment. This study was to evaluate the QOL of patients with gastric cancer or colorectal cancer, and to investigate the factors affecting their QOL. METHODS: Structured questionnaire EORTC QLQ C30 was used to evaluate the QOL of 52 gastric cancer patients and 50 colorectal cancer patients from Feb. 1, 2005 to Aug. 31, 2006. The QOL were compared by t test and one-way analysis of variance (ANOVA). The correlations of the items, facets, and domains of EORTC QLQ C30 to clinical stage were analyzed by optimal scaling regression and discriminant analysis. The correlations of the items, facets, and domains of EORTC QLQ C30 to overall QOL were analyzed by multiple linear regression analysis. RESULTS: The patients at early stages, or with higher education, or received combined treatment, had high functional scale and global health status (GH)/QOL score and low symptom scale and single item score, and had better QOL. Age and sex had no influence on QOL. GH scores of gastric cancer patients were lower than those of colorectal cancer patients, indicating that the QOL of gastric cancer patients was poorer than the QOL of colorectal cancer patients. CONCLUSION: Clinical stage, education, and treatment pattern are important factors affecting the QOL of patients with gastrointestinal cancer.