| 硝苯啶缓释微球在兔体内的药物动力学及生物利用度 |
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| 引用本文： | 傅崇东,蒋雪涛,胡晋红,万兴旺. 硝苯啶缓释微球在兔体内的药物动力学及生物利用度[J]. 第二军医大学学报, 1996, 0(3) |
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| 作者姓名： | 傅崇东 蒋雪涛 胡晋红 万兴旺 |
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| 作者单位： | 第二军医大学药学院药剂学教研室，第二军医大学长海医院药剂科 |
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| 摘 要： | 目的：研究自制的硝苯啶缓释微球在兔体内的药物动力学及生物利用度。方法：以瑞士产硝苯啶缓释片为参比对照品，以组间对照方式，给予新西兰兔单剂量口服１０ｍｇ缓释微球和对照品。用毛细管气相色谱法测定血浆中药物浓度。结果：硝苯啶缓释微球相对于缓释片的生物利用度为９９．７％，两种制剂的达峰时间、达峰浓度和体内驻留时间等参数均无显著性差异（Ｐ＞０．０５）。微球的体内吸收百分率与体外溶出百分率呈显著相关性（Ｐ＜０．０１）。结论：自制的硝苯啶缓释微球具有较好的生物利用度和缓释作用，与进口缓释片剂具有生物等价性。
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| 关 键 词： | 硝苯啶；缓释微球；药代动力学；生物利用度；兔 |
The pharmacokinetics and bioavailability of nifedipine sustained-release microspheres in rabbits |
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| Fu Chongdong,Jiang Xuetao,Hu Jinhong,Wan Xingwang. The pharmacokinetics and bioavailability of nifedipine sustained-release microspheres in rabbits[J]. Former Academic Journal of Second Military Medical University, 1996, 0(3) |
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| Authors: | Fu Chongdong Jiang Xuetao Hu Jinhong Wan Xingwang |
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| Abstract: | To investigate the pharmacokinetics and bioavailability of nifedipine sustained-release microspheres in rabbits. Methods: The nifedipine sustained-release microspheres .and the commercial retard tablet as a control, containing 10 mg nifedipine respectively, were orally administrated to rabbits. The plasma nifedipine concentrations were determined using GC-ECD. Results: The relative bioavailability of nifedipine sustainedrelease microspheres against retard tablet was 99.7 % . The analysis of variance of the pharmacokinetic parameters-AUC, Cmas, Tmas and MRT, for the two formulations , did not show any statistical difference(P>0.05).A significant linear correlation (P<0.01 ) existed between the dissolution in vitro and the absorption in-vivo for the microspheres. Conclusion: The nifedipine sustained-release microspheres show good bioavailability and sustained-release behavior in-vivo, and is bioequivalent to commercial retard tablet in all respects. |
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| Keywords: | nifedipine sustained-release microspheres pharmacokinetics bioavailability rabbits |
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