| 大鼠外伤性脑水肿单胺神经递质的改变 |
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| 引用本文： | 杨林,王国安,孙璇. 大鼠外伤性脑水肿单胺神经递质的改变[J]. 武汉大学学报(医学版), 2000, 21(2): 136-138 |
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| 作者姓名： | 杨林 王国安 孙璇 |
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| 作者单位： | 1. 武汉同济医院创伤外科,武汉,430071
2. 湖北医科大学,附一医院神经外科,武汉,430060 |
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| 摘 要： | 目的 :研究大鼠急性脑损伤后脑组织单胺神经递质的变化。方法 :32只大鼠随机分成 4组 ,以落体致伤的方法造成右顶叶脑挫裂伤 ,测定伤后 2 ,6 ,2 4h脑挫裂伤灶周围脑含水量、Na+ Ca2 + 和单胺神经递质含量。结果 :脑损伤后随时间延长脑水肿程度逐渐增加 ,伤后 2 4h达高峰 ,脑组织Na+ 、Ca2 + 和单胺神经递质含量也随时间延长而增加。结论 :脑损伤后脑内儿茶酚胺类神经递质的过量释放 ,是外伤性脑水肿发展的重要因素之一。
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| 关 键 词： | 脑损伤 脑水肿 儿茶酚胺素 钠 钙 大鼠 |
The Change of Catecholamine Following Traumatic Brain Injuries in Rats |
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| Yang Lin,Wang Guoan,Sun Xuan. The Change of Catecholamine Following Traumatic Brain Injuries in Rats[J]. Medical Journal of Wuhan University, 2000, 21(2): 136-138 |
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| Authors: | Yang Lin Wang Guoan Sun Xuan |
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| Abstract: | Objective:To study the change of catecholamine (CA) following traumatic brain injury.Methods:32 adult SD rats were randomly divided into four groups(8 in each group) as sham nontraumatic group,2 h,6 h,24 h postinjury group.The right pareital cerebral lobe contusions were produced with a weight dropping method.Specimens around contusion were gathered.Concentrations of sodium,calciumion,CA and water content in the brain tissues were evaluated.Results:The result showed that the sodium,calcium concentration,contend of brain water and CA in brain tissue around contusion increased continuously after 2 horus postinjury.Conclusion:The experiment suggested that increases of sodium,calcium and CA following the acute traumatic brain injury is important in mechanisms of neuronal damage after brain injury. |
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| Keywords: | brain injuries brain edema catecholamines sodium calcium rats |
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