克拉霉素、奥美拉唑、阿莫西林三联治疗儿童幽门螺杆菌感染

目的 :探讨克拉霉素、奥美拉唑、阿莫西林三联疗法治疗儿童幽门螺杆菌 (Hp)感染的疗效。方法 :57例经13C尿素呼吸试验 ( 13C ureabreathtest:13C UBT)及血清Hp IgG证实为Hp感染的腹痛病儿 ,男性 2 9例 ,女性 2 8例 ,年龄 ( 6.6±s2 .5)a ,用克拉霉素 2 50mg ,po ,bid ,奥美拉唑 2 0mg ,po ,qd ,阿莫西林 2 50mg ,po ,tid ,联合治疗 1wk ,于停药后 4wk复查13C UBT。结果 :57例中Hp感染致腹痛完全消失者 2 3例 ,好转 32例 ,无效2例 ,总有效率 96% ;50例Hp转阴 ,Hp根除率88%。副作用少。结论 :本疗法治疗儿童Hp感染临床效果显著 ,且安全。

Clarithromycin, omeprazole, amoxicillin in triple therapy for Helicobactor pylori infection in children

AIM: To observe the efficacy of clarithromycin, omeprazole, amoxillin in triple treatment of Helicobaotor pylori ( Hp ) infection in children. METHODS: Fifty seven children with abdominal pain and Hp infection identified by 13 C-UBT and Hp -IgG were given one week therapy of clarithromycin 250 mg, po , bid, omeprazole 20 mg, po , qd, amoxillin 250 mg, po , tid. The patients were examined by C-UBT in 4 wk after stopping giving drugs. RESULTS: It showed that recurrent abdominal pain(RAP) disappeared in 23 of 57 patients with Hp infection, improved in 32 patients, 2 have no efficacy, and the total efficiency was 96%; Hp became negative in 50 patients after therapy and the Hp eradication rate is 88%. CONCLUSION: The treatment of Hp infection in children using clarithromycin, omeprazole, amoxillin is very effective and the side effect is moderate.