首发精神分裂症患者血清甲状腺激素检测临床研究

目的探讨甲状腺功能与首发精神分裂症之间的相关性及临床意义。方法自编调查表收集2011年4月-2013年8月在芜湖市第四人民医院住院治疗的首发精神分裂症患者84例及门诊健康体检者46例,采用cobase411电化学发光全自动免疫分析仪分别测定两组血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离甲状腺激素(FT3、FT4)和促甲状腺激素(TSH)水平,并应用SPSS 13.0统计软件进行χ2检验及t检验。结果患者组血清T4(100.88±24.10)、FT3(4.64±4.64)低于正常对照组血清T4(108.09±15.13)、FT3(4.97±4.97),差异有统计学意义(P=0.039,P=0.012),血清T3、FT4、TSH与正常对照组比较,差异无统计学意义(P0.05);首发精神分裂症女性组血清FT3(4.45±0.82)、FT4(16.40±3.48)与男性组血清FT3(5.07±1.00)、FT4(18.51±3.37)比较差异有统计学意义(P均0.05)。结论首发精神分裂症,尤其是女性精神分裂症的发生与甲状腺异常高度相关,应采取有效措施应对。

Clinical research of serum thyroid hormone detection in first-episode schizophrenia patients

Objective To explore the relationship between thyroid function and first-episode schizophrenia and clinical signifi-cance. Methods A total of 84 unrelated schizophrenia inpatients were recruited from the Fourth People＇s Hospital of Wuhu City from December 2008 to August 2010. Self-made questionnaire was applied to collect the demographic data of all subjects. The cobas？ e411 automatic electrochemiluminescence immunoassay analyzer was determined respectively to the two groups of serum thyroid glycine （T3）,thyroxine（T4）,freethyroidhormones（FT3,FT4）andthyroid-stimulatinghormone（TSH）level. AndtheSPSS13.0statis-tical software was carried on the chi-square test and t test. Results The serum T4（100.88 ±24.10） and FT3（4.64 ±4.64）levels in first-episode schizophrenia patients were lower than those in normal controls（108. 09 ± 15. 13）, P=0. 039;（4. 97 ± 4. 97）,P=0. 012]. No significant differences were found in serum T3, FT4 and TSH levels between first-episode schizophrenia patients and con-trols（〉0. 05）. The serum FT3 （4. 45 ± 0. 82） and FT4 （16. 40 ± 3. 48） levels in the female first-episode schizophrenia patients were significantly lower than that in the male group（5. 07 ± 1. 00）,P〈0. 05;（18. 51 ± 3. 37）,P〈0. 05]. Conclusion First-epi-sode schizophrenia, especially female, the incidence of that are highly correlated with thyroid abnormalities , and effective measures should be taken to deal with.