综合心理干预对精神分裂症患者认知功能及生活质量的影响研究

目的探讨综合心理干预对精神分裂症患者认知功能及生活质量的效果,为改善精神分裂症患者生活质量及认知功能供依据。方法本研究为开放式随机对照临床试验。选取符合《国际疾病分类(第10版)》(ICD-10)中精神分裂症诊断标准的住院患者120例,采用随机数字表法分为研究组(n=59)和对照组(n=61)。两组均进行常规药物治疗,研究组在此基础上进行综合心理干预,包括支持性心理治疗、认知行为治疗、家庭心理治疗、健康教育、工娱治疗,共16周。采用阳性和阴性症状量表(PANSS)、世界卫生组织生存质量量表简表(WHOQOLBREF)、认知功能成套测试(MCCB)对两组患者进行疗效评定。并随访1年,比较两组患者的疾病复发率。结果两组在治疗后各时点量表评分与治疗前相比差异有统计学意义(P0.05)。治疗后两组同期各量表评分比较差异有统计学意义(P0.05)。研究组复发9例(15%),对照组复发16例(26.7%),两组复发率比较差异有统计学意义(P0.01)。结论综合性心理干预能有效改善精神分裂症患者的生活质量和认知功能,降低复发率。

Effects of psychological intervention on cognitive function and quality of life in patients with schizophrenia

Objective To explore the efficacy of psychological intervention on cognitive function and quality of life in patients with Schizophrenia ,and so as to find the effective method for improving the quality of life and cognitive function of Schizophrenia pa-tients. Methods In the single blind ,randomized controlled study, 120 schizophrenia patients met the diagnosis of Mental and behav-ior disorders of International Classification of Diseases （ ICD -10 ） , were randomly assigned to psychological intervention group （ n =60）,and simple drug treatment group （n=60）. The patients accepted 16 sessions of psychological intervention respectively, including cognitive behavioral therapy,supportive psychotherapy,health education,work and recreational et al. Positive and Negative Symptoms Scale（PANSS）, the World Heath Organization Quality of Life（WHOQOL-BREF）, MATRIOCS（Measurement And Treatment Re-search to Improve Cognition in Schizophrenia） ,the cognitive function of complete sets of testing（ MCCB） were used to assess the effica-cy at baseline and other point . Follow-up of 1 year, compare two groups of patients with recurrence rate. Results Rating scale of tow groups have obviously improved after treatment, and the team compared with control group have significant differences（P〈0. 01）. The recurrence rate of the team is significant decrease. Conclusion Psychological intervention could improve the quality of life and cognitive function in patients with Schizophrenia and reduce patients recurrence rate.