| 妊娠期糖尿病丙二醛、超氧化物歧化酶和一氧化氮的变化 |
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| 引用本文： | 冯玉昆,祁文瑾,李白鸾,吕群英.妊娠期糖尿病丙二醛、超氧化物歧化酶和一氧化氮的变化[J].昆明医学院学报,2003,24(1):66-68. |
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| 作者姓名： | 冯玉昆 祁文瑾 李白鸾 吕群英 |
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| 作者单位： | 昆明医学院第一附属医院妇产科,昆明,650032 |
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| 基金项目： | 云南省教育厅科研基金资助项目 (编号 :0 5 - 93) |
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| 摘 要： | 目的 :测定妊娠期糖尿病 (GDM)孕妇血清丙二醛 (MDA)、超氧化物歧化酶 (SOD)和一氧化氮(NO)含量 ,寻找监测GDM病情变化的临床指标 .方法 :采集 30例GDM患者和 4 5例正常孕妇血清 ,以硫代巴比妥酸 (TBA)比色法、黄嘌呤氧化酶法、硝酸还原酶法分别测定MDA ,SOD和NO含量 .结果 :GDM组SOD ,NO含量均显著低于对照组 (P <0 0 5 ) ,MDA含量在两组无显著差异 ,但与GDM患者控制情况相关 .结论 :MDA ,SOD ,NO的变化与GDM的病理过程有关 ,MDA可作为临床监测GDM病情的指标
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| 关 键 词： | 妊娠期糖尿病 丙二醛 超氧化物歧化酶 一氧化氮 |
| 文章编号： | 1003-4706(2003)01-0066-03 |
| 修稿时间： | 2002年4月30日 |
Study on MDA, SOD and NO in Gestatioal Diabetes Mellitus |
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| FENG Yu-kun,QI Wen-jin,LI Bai-luan,LU Qun-ying.Study on MDA, SOD and NO in Gestatioal Diabetes Mellitus[J].Journal of Kunming Medical College,2003,24(1):66-68. |
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| Authors: | FENG Yu-kun QI Wen-jin LI Bai-luan LU Qun-ying |
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| Abstract: | Objective: The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) were measured to find out the clinical index in GDM. Methods: Blood samples of 30 GDM and 45 unrelated normal controls were used to measure MDA, SOD and NO levels with methods of TBA, xanthine oxidase and nitric reductase. Results: In GDM group, the levels of SOD and NO were significantly lower, P<0 05. There was no difference of MDA levels between GDM patients and control subjects, but the levels of MDA associated with the concentrations of glucose in clinical treatment. Conclusion: The levels of MDA, SOD and NO were variable with pathological change of GDM. The serum levels of MDA may be clinical index of GDM. |
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| Keywords: | Gestational diabetes mellitus Malondialdehyde Superoxide dismutase Nitric oxide |
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