Assignment of dioxin-inducible cytochrome P-450 gene family to Chinese hamster chromosome 4 |
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| Authors: | C. Edgar Hildebrand Raymond L. Stallings Frank J. Gonzalez Daniel W. Nebert |
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| Affiliation: | (1) Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, 20205 Bethesda, Maryland;(2) Present address: Los Alamos National Laboratory, Genetics Group, 87545 Los Alamos, New Mexico |
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| Abstract: | The 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P-450gene family (P1-450and P3-450in the C57BL/6N mouse)has recently been localized to mouse chromosome 9. In the present study, HindIII-digested DNA from Chinese hamster, mouse, and 20 Chinese hamster × mouse somatic cell hybrids and subclones segregating hamster chromosomes was probed with the mouse P1-450and P3-450full-length cDNA clones. Hamster P-450gene fragments (6.0 and 7.4 kb) were assigned to Chinese hamster chromosome 4. These data are consistent with linkage conservation among these two P-450sequences and four other loci on mouse chromosome 9 that map to hamster chromosome 4. |
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