| 非编码RNA与真核生物基因表达调控:从染色体到蛋白质 |
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| 引用本文： | 曹国军,邵宁生,范明.非编码RNA与真核生物基因表达调控:从染色体到蛋白质[J].医学分子生物学杂志,2005,2(1):42-44. |
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| 作者姓名： | 曹国军 邵宁生 范明 |
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| 作者单位： | 军事医学科学院基础医学研究所,北京市,100850;军事医学科学院基础医学研究所,北京市,100850;军事医学科学院基础医学研究所,北京市,100850 |
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| 摘 要： | 非编码RNA(ncRNA)在真核生物基因表达调控中至少起着部分关键的作用,这是由RNA本身的化学性质决定的。根据功能,ncRNA可以大致分成“看家RNA”与“调控RNA”。ncRNA的调控,从遗传信息的载体(DNA和染色质)一直到遗传信息的表达产物(蛋白质)的产生,所有生物过程中都有着极其重要的作用。将来的挑战是确定基因组中存在多少ncRNA,并研究它们所有的功能。
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| 关 键 词： | 非编码RNA 微RNA 基因表达 |
| 修稿时间： | 2004年6月30日 |
Noncoding RNAs and Eukaryote Gene Expression Regulation: from Chromosomes to Proteins |
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| CAO Guojun,SHAO Ningsheng,FAN Ming Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing,China.Noncoding RNAs and Eukaryote Gene Expression Regulation: from Chromosomes to Proteins[J].Journal of Medical Molecular Biology,2005,2(1):42-44. |
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| Authors: | CAO Guojun SHAO Ningsheng FAN Ming Institute of Basic Medical Sciences Academy of Military Medical Sciences Beijing China |
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| Institution: | CAO Guojun,SHAO Ningsheng,FAN Ming Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing,100850,China |
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| Abstract: | In recent years, noncoding RNAs (ncRNAs) have been shown to constitute key elements implicated in a number of regulatory mechanisms in the eukaryotes. Broadly speaking, according to their functions, noncoding RNAs can be divided into two classes: housekeeping RNAs and regulatory noncoding RNAs. The ncRNAs are involved in the regulation of expression from mediating chromatin modifications to translation. A big challenge lor the future will be to identify the whole complement of ncRNAs and to elucidate their functions. |
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| Keywords: | noncoding RNAs microRNAs gene expression |
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