甲壳素短纤维增强聚己内酯复合材料体外降解实验研究

将纯聚己内酯（PCL）、甲壳素短纤维增强PCL复合材料和聚DL-乳酸分别置于生理盐水溶液中,进行体外降解实验研究。于2、4、8、12、16、24周分别取材,测试降解液pH值、试样失重率及力学性能的变化,并行扫描电镜观察。结果显示甲壳素短纤维增强PCL初始强度大于纯PCL,在降解过程中,浸泡液pH值呈弱酸性和中性,失重速率快于纯PCL,力学性能先高后低,强度和模量值24周与初始值相差不大。通过以上体外降解实验可以得出结论：PCL树脂复合甲壳素纤维后,加快降解速度,提高力学性能,缓冲材料局部pH值的下降,是一种很有前途的胸壁缺损修补及骨科内固定材料。

The Degradation Performance of Chitin Short Fiber Reinforced Polycaprolactone Composite in Vitro

We have investigated the degradation of pure Polycaprolactone(PurePCL)and chitin short fiber reinforced Polycaprolactone composite(SFRP)in vitro in order to provide useful scientific basis for clinical application.PurePCL,SFRP and DL-PLA were immersed in 0.9% NaCL solution for periods of 2,4,8,12,16 and 24 weeks.Then pH values in immersing solution,weight loss and mechanical properties of tested materials were measured and SEM was used to study the change of the materials in the process of degradation.It was shown that the initial strength of SFRP was much higher than that of PurePCL.In the process of degradation of SFRP,the pH values maintained weak acid or remianed neutral.The rate of weight loss of SFRP was faster than that of PurePCL,but slower than that of DL-PLA.The strength and modulus of SFRP did not change much in 24 weeks,compared with the initial ones.In conclusion,the composites have excellent properties and may be optimal for clinical use in reconstruction of chest wall defects as well as in internal fixation of bone fracture.