冠心病患者血清TBIL与OX-LDL水平的变化及其相关性

目的探讨冠心病(Coronary heart disease,CHD)患者血清总胆红素(Total bilirubin,TBIL)与氧化修饰低密度脂蛋白(1ow density lipoprotein,OX-LDL)水平的变化及其相互关系. 方法采用氧化酶法和ELISA(Enzyme-linkedimmunoadsordent assay)法分别检测血清TBIL及血浆OX-LDL水平. 结果冠心病患者血清TBIL水平显著低于正常对照组(P＜0.01),而血浆OX-LDL水平则明显高于正常对照组(P＜0.01);冠心病患者血清TBIL与血浆OX-IDL水平呈显著负相关(r=-0.59,P＜0.01),而正常对照组这两成分间则无明显相关性(r=-0.18,P＜0.05).结论冠心病患者血清TBIL水平显著降低而OX-LDL显著升高;冠心病患者血清TBIL抗LDL氧化能力的减弱可能是导致OX-LDL升高的重要原因之一.

Study on the relationship between total bilirubin and oxidized low density lipoprotein in patients with coronary heart disease

Objective To investigate the changes of total biliruin (TBIL) and oxidized low density lipoprotein (OX-LDL) and the relationship in patients with coronary heart disease(CHD). Methods Total bilirubin is measured by analysis Plasma OX-LDL was measured by double antibody enzyme-linked immunoadsordent assay. Results Serum level of TBIL is greatly decreased in patients with CHD as compared with healthy subjects(P<0.01), while plasma level of OX-LDL is markedly increased in patients with CHD as compared with healthy subjects (P<0.01). Serum level of TBIL is inversely correlated with plasma level of OX-LDL in patients with CHD(r =-0.59, P<0.01). There is no difference in serum level of TBIL and plasma level of OX-LDL in healthy subjects. Conclusion TBIL plays roles against LDL oxygenation in CHD and the impairment of anti-oxidate ability of TBIL may be an important factor causing OX-LDL level to be increased in patients with CHD.