Application of non-invasive detection of peripheral vascular dysfunction in ovarian hyperstimulation syndrome (OHSS): A pilot study of clinical relevance |
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Authors: | Tzu-Hsuan Chin Chia-Pin Lin Shuenn-Dhy Chang Hsin-Shih Wang Hong-Yuan Huang Yung-Kuei Soong Hsien-Ming Wu Pao-Hsien Chu |
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Institution: | 1. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan, ROC;2. Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan, ROC |
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Abstract: | ObjectiveThe current study tested the hypothesis that vascular endothelial function, as reflected by the reactive hyperemia index (RHI), and biochemical factors, including VEGF, TNFα, CRP, inhibin A, and inhibin B, were involved in the pathogenesis of ovarian hyperstimulation syndrome (OHSS).Materials and methodsThis study was conducted between June 2010 and June 2012, enrolling 15 patients with OHSS and 6 healthy control subjects <45 years of age. Detailed clinical parameters were reviewed, including serum VEGF, TNFα, CRP, inhibin A, inhibin B, and hematocrit. RHI assessed by novel automatic peripheral arterial tonography was used to evaluate the vascular endothelial function.ResultsTwenty-one subjects were evaluated. There was no significant difference between patients with OHSS and control subjects with respect to VEGF, TNFα, CRP, inhibin A and inhibin B. The RHI was not significantly different between patients with OHSS and control subjects (mean, 1.8 ± 0.4 vs. 1.7 ± 0.2). The hematocrit was significantly different between patients with OHSS and control subjects.ConclusionsOur preliminary data did not reveal direct evidence of vascular endothelial dysfunction in patients with OHSS. To identify whether RHI could reflect vascular endothelial dysfunction in patients with OHSS, more cases with different severities of OHSS should be recruited in the future study. |
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Keywords: | Corresponding author Ovarian hyperstimulation syndrome Vascular dysfunction Reactive hyperemia index Vascular endothelial growth factor |
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