Incremental risk of cardiovascular disease and/or chronic kidney disease for future ASCVD and mortality in patients with type 2 diabetes mellitus: ACCORD trial |
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Authors: | Mary Branch Charles German Alain Bertoni Joseph Yeboah |
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Affiliation: | 1. Heart and Vascular Center of Excellence, Wake Forest Baptist Health, Winston Salem, NC, United States of America;2. Department of Epidemiology and Public Health, Wake Forest Baptist Health, Winston Salem, NC, United States of America |
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Abstract: | BackgroundCardiovascular disease (CVD) and chronic kidney disease (CKD) are complications of type 2 diabetes mellitus (DM). Current cholesterol guidelines recommend the same prevention strategy for patients with DM alone as patients with DM + CKD. However, the incremental risk of these common complications for incident cardiovascular disease and mortality has not been well studied.MethodsWe compared the incremental risk of having DM + CKD, DM + CVD and DM + CVD + CKD in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial participants for incident CVD as the primary outcome and all-cause mortality.ResultsAfter a mean (SD) follow up of 4.7(1.4) years, 1,046(10%) participants developed CVD. DM +vCKD, DM + CVD, and DM + CKD + CVD had a significantly increased risk of the primary outcome compared to DM alone [adjusted hazard ratio(95%CI): 1.41 (1.06-1.89), p = 0.02; 2.20 (1.92-2.53), p < 0.001); 2.35 (1.81-3.04), p < 0.001), respectively]. All-cause mortality had a graded increased risk compared to the reference group [adjusted hazard ratio(95%CI): 1.39 (1.01-1.90), p = 0.04; 1.29 (1.51-2.12), p < 0.0001; 2.36 (1.75-3.13), p < 0.0001), respectively].ConclusionOur post hoc analysis shows an incremental graded risk for CVD outcomes and all-cause mortality with the development of CKD and/or CVD in individuals with DM. |
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Keywords: | Corresponding author at: Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, United States of America. Diabetes mellitus Macrovascular complications Mortality Risk Cardiovascular Disease |
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