Early lead exposure and childhood adiposity in Mexico city |
| |
Authors: | Yun Liu Karen E Peterson Kathleen Montgomery Brisa N Sánchez Zhenzhen Zhang Myriam C Afeiche David E Cantonwine Adrienne S Ettinger Alejandra Cantoral Lourdes Schnaas Howard Hu Martha M Te?llez-Rojo |
| |
Institution: | 1. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA;3. Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, US;4. Nestle? Research, Vers-chez-les-Blanc, 1000 Lausanne, Switzerland;5. Divison of Maternal Fetal Medicine, Department of OB/GYN, Brigham and Women''s Hospital, Boston, MA, USA;6. Centro de Investigacion en Nutrición y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico;7. Department of Occupational and Environmental Health Sciences, University of Washington School of Public Health, Seattle, WA USA |
| |
Abstract: | BackgroundPrenatal and early childhood lead exposures have been associated with reduced weight in infants and young children, while studies that have examined such associations in children during peripubescence are rare.ObjectivesWe investigated the associations of prenatal and early-life exposure to lead with indices of adiposity in peripubertal children living in Mexico City.MethodsMaternal bone lead (as a proxy for cumulative fetal exposure) was assessed at 1 month postpartum. Blood samples were obtained from children annually from 1 to 4 years. Multivariable linear regression models were used to examine the association between each lead biomarker and BMI z-score, waist circumference, sum of skinfolds and body fat percentage in 248 children aged 8–16 years.ResultsAfter adjusting for covariates, maternal patella lead was associated with lower child BMI z-score (β = ?0.02, 95% CI: 0.03, ?0.01, p = 0.004), waist circumference (β = ?0.12 cm, 95% CI: 0.22, ?0.03, p = 0.01), sum of skinfolds (β = ?0.29 mm, 95% CI: 0.50, ?0.08, p = 0.007) and body fat percentage (β = ?0.09%, 95% CI: 0.17, ?0.01, p = 0.03). No significant associations were detected from the postnatal exposure period.ConclusionsWe observed a significant and inverse association of prenatal lead exposure with body composition in Mexican children, suggesting the potential role of early lead exposure in the fetal programming of child growth. Further research on the biological mechanisms underlying these associations is needed. |
| |
Keywords: | Corresponding author 1867 SPH I 1415 Washington Heights Ann Arbor MI 48109 USA Bone lead Pregnancy Adiposity BMI Body fat percentage |
本文献已被 ScienceDirect 等数据库收录! |
|