Cardiac Biomarkers Predict Large Vessel Occlusion in Patients with Ischemic Stroke |
| |
Authors: | Andrew Chang Brittany Ricci Brian Mac Grory Shawna Cutting Tina Burton Katarina Dakay Mahesh Jayaraman Alexander Merkler Michael Reznik Michael P Lerario Christopher Song Hooman Kamel Mitchell SV Elkind Karen Furie Shadi Yaghi |
| |
Institution: | 2. Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island;3. Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Providence, Rhode Island;4. Departments of Neurology and Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York;5. Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York |
| |
Abstract: | Background and PurposeCardiac biomarkers may help identify stroke mechanisms and may aid in improving stroke prevention strategies. There is limited data on the association between these biomarkers and acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). We hypothesized that cardiac biomarkers (cardiac troponin and left atrial diameter LAD]) would be associated with the presence of LVO.MethodsData were abstracted from a single center prospective AIS database over 18 months and included all patients with AIS with CT angiography of the head and neck. The presence of LVO was defined as proximal LVO of the internal carotid artery terminus, middle cerebral artery (M1 or proximal M2), or basilar artery. Univariate analyses and predefined multivariable models were performed to determine the association between cardiac biomarkers (positive troponin troponin ≥0.1 ng/mL] and LAD on transthoracic echocardiogram) and LVO adjusting for demographic factors (age and sex), risk factors (hypertension, diabetes, hyperlipidemia, history of stroke, congestive heart failure, coronary heart disease, and smoking), and atrial fibrillation (AF).ResultsWe identified 1234 patients admitted with AIS; 886 patients (71.8%) had vascular imaging to detect LVO. Of those with imaging available, 374 patients (42.2%) had LVO and 207 patients (23.4%) underwent thrombectomy. There was an association between positive troponin and LVO after adjusting for age, sex and other risk factors (adjusted OR 1.69 1.08-2.63], P = .022) and this association persisted after including AF in the model (adjusted OR 1.60 1.02-2.53], P = 0.043). There was an association between LAD and LVO after adjusting for age, sex, and risk factors (adjusted OR per mm 1.03 1.01-1.05], P = 0.013) but this association was not present when AF was added to the model (adjusted OR 1.01 0.99-1.04], P = .346). Sensitivity analyses using thrombectomy as an outcome yielded similar findings.ConclusionsCardiac biomarkers, particularly serum troponin levels, are associated with acute LVO in patients with ischemic stroke. Prospective studies are ongoing to confirm this association and to test whether anticoagulation reduces the risk of recurrent embolism in this patient population. |
| |
Keywords: | Address correspondence to Shadi Yaghi MD Department of Neurology The Warren Alpert Medical School of Brown University 353 Eddy Street APC 530 Providence RI 02903 Troponin left atrial enlargement stroke large vessel occlusion cardiac biomarkers |
本文献已被 ScienceDirect 等数据库收录! |
|