Efficacy of acetaminophen versus ibuprofen for the management of rotator cuff-related shoulder pain: Randomized open-label study |
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Authors: | Yazed AlRuthia Sultan Alghadeer Bander Balkhi Haya M. Almalag Hana Alsobayel Faris Alodaibi Fakhr Alayoubi Amal S. Alkhamali Samar Alshuwairikh Futoun N. Alqahtani Hisham Alsanawi |
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Affiliation: | 1. Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;2. Pharmacoeconomics Research Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;3. Pharmacy Education Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;4. Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia;5. Department of Pharmaceutical Care, King Saud University Medical City, Riyadh, Saudi Arabia;6. Saudi Food and Drug Authority, Riyadh, Saudi Arabia;7. King Abdullah Hospital, Riyadh, Saudi Arabia;8. Department of Orthopedics Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia |
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Abstract: | BackgroundShoulder pain related to the rotator cuff (RC) is one of the most common and bothersome musculoskeletal complaints. Pharmacologic treatment most often includes acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen. However, data allowing comparison of the efficacy of these two drugs are very limited. We compared the therapeutic outcomes of acetaminophen and ibuprofen in the management of RC-related pain.MethodsThis was an open-label, two-center, active-control, prospective randomized clinical trial. Participants were assigned randomly to acetaminophen or ibuprofen treatment groups. The acetaminophen dose was 500 mg every 6–8 h, and it was 400–800 mg every 6–8 h for ibuprofen. The impact of the treatment was measured by Shoulder Pain and Disability Index (SPADI), Quick Disabilities of the Arm, Shoulder, and Hand (Quick-DASH) and World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaires at baseline and after 6 weeks of therapy.ResultsThirty-three patients completed the study; 20 treated with ibuprofen and 13 with acetaminophen. Patients in both groups were comparable at baseline with regard to SPADI, Quick-DASH, and WHOQOL-BREF scores. After 6 weeks of treatment, patients receiving ibuprofen, but not acetaminophen, reported an improvement in pain severity and functional activity (as measured by SPADI and Quick-DASH). Patients taking acetaminophen, but not ibuprofen, reported improvement in the physical and environmental domains of WHOQOL-BREF scores.ConclusionsIbuprofen and acetaminophen provide benefits to patients suffering from RC-related pain. However, the type of improvement perceived by patients differed between these two medications. |
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Keywords: | Corresponding author at: P.O. Box 2454, Riyadh 11451, Saudi Arabia. Pain Shoulder injuries Quality of life Analgesics |
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