Dietary instructions focusing on meal-sequence and nutritional balance for prediabetes subjects: An exploratory,cluster-randomized,prospective, open-label,clinical trial |
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Authors: | Daisuke Yabe Hitoshi Kuwata Yuuka Fujiwara Mayuka Sakaguchi Shota Moyama Noboru Makabe Kenta Murotani Hiroshi Asano Sanae Ito Hideyuki Mishima Hideto Takase Noriyasu Ota Yusuke Seino Yoshiyuki Hamamoto Takeshi Kurose Yutaka Seino |
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Affiliation: | 1. Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan;2. Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan;3. Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan;4. Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;5. Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka, Japan;6. Center for Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, Osaka, Japan;7. Biostatistics Center, Graduate School of Medicine, Kurume University, Fukuoka, Japan;8. Kansaimedicalnet Co., Ltd., Kyoto, Japan;9. Kansai Electric Power Company, Co., Ltd., Osaka, Japan;10. Kao Corporation, Tokyo, Japan.;11. Department of Endocrinology and Metabolism, Fujita Health University School of Medicine, Toyoake, Japan;12. Nakanoshima clinic, Osaka, Japan |
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Abstract: | BackgroundAlthough lifestyle modifications are known to be effective in type 2 diabetes (T2D) as well as in prediabetes, adherence to a healthy diet is difficult for some, and interventions of lifestyle modifications need to be revised occasionally. Meal sequence has been gaining attention as a part of a healthy diet among T2D individuals to improve glycemia and body weight. In addition, a dietary instruction program, SMART Washoku®, which can help individuals to consume a more nutritionally balanced diet, has been developed.MethodsThe current exploratory trial was designed to examine the effects of dietary instructions focusing on meal sequence and nutritional balance in individuals with prediabetes in the Japanese national health check-up and guidance program. Participants were cluster-randomized into three groups: Group A, receiving a conventional health guidance program (n = 11); Group B, receiving health guidance with dietary instructions focusing on meal sequence (n = 18); and Group C, receiving health guidance with dietary instructions focusing on nutritional balance (n = 13). Participants received health guidance education and various measurements before and 6 months after the instructions.ResultsBody weight in Group B was significantly reduced compared to that in Group A, with similar adherence, while the effects on glycemia were similar between the two Groups. Body weight reduction was greater in Group C compared to that in Group A, although adherence in Group C was significantly lower than that in Group A.ConclusionThe group receiving health guidance with dietary instructions focusing on meal sequence exhibited similar adherence and greater reduction in body weight than the group receiving conventional health guidance. |
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Keywords: | Corresponding authors at: Yutaka Seino Distinguished Center for Diabetes Research Kansai Electric Power Medical Research Institute 1-5-6 Minatojimaminamimachi Chuo-ku Kobe 650-0047 Japan. |
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