Monaural 40-Hz auditory steady-state magnetic responses can be useful for identifying epileptic focus in mesial temporal lobe epilepsy |
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Authors: | Teppei Matsubara Katsuya Ogata Naruhito Hironaga Taira Uehara Takako Mitsudo Hiroshi Shigeto Toshihiko Maekawa Shozo Tobimatsu |
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Affiliation: | 1. Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Japan;2. Epilepsy and Sleep Center, Fukuoka Sanno Hospital, Fukuoka, Japan;3. Department of Neuropsychiatry, Amekudai Hospital, Japan |
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Abstract: | ObjectivePatients with mesial temporal lobe epilepsy (mTLE) often exhibit central auditory processing (CAP) dysfunction. Monaural 40-Hz auditory steady-state magnetic responses (ASSRs) were recorded to explore the pathophysiology of mTLE.MethodsEighteen left mTLE patients, 11 right mTLE patients and 16 healthy controls (HCs) were examined. Monaural clicks were presented at a rate of 40 Hz. Phase-locking factor (PLF) and power values were analyzed within bilateral Heschl’s gyri.ResultsMonaural 40-Hz ASSR demonstrated temporal frequency dynamics in both PLF and power data. Symmetrical hemispheric contralaterality was revealed in HCs. However, predominant contralaterality was absent in mTLE patients. Specifically, right mTLE patients exhibited a lack of contralaterality in response to left ear but not right ear stimulation, and vice versa in left mTLE patients.ConclusionThis is the first study to use monaural 40-Hz ASSR with unilateral mTLE patients to clarify the relationship between CAP and epileptic focus. CAP dysfunction was characterized by a lack of contralaterality corresponding to epileptic focus.SignificanceMonaural 40-Hz ASSR can provide useful information for localizing epileptic focus in mTLE patients. |
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Keywords: | Corresponding author at: Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan. Fax: +81 92 642 5545. Central auditory processing Mesial temporal lobe epilepsy Monaural auditory steady-state response Temporal frequency dynamics Contra-laterality index Magnetoencephalography |
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