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Dynamic photoacoustic imaging of neurovascular coupling in salivary glands |
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| Authors: | Laurie J Rich Eftekhar Rajab Bolookat Mukund Seshadri |
| Institution: | 1. Department of Oral Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA;2. Department of Radiology-Medical Physics Program, University at Buffalo - Jacobs School of Medicine and Biomedical Sciences, 955 Main Street, Buffalo, NY 14203, USA;3. Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA |
| Abstract: | The purpose of this study was to apply photoacoustic imaging (PAI), a relatively new imaging method, to non-invasively map neurovascular dynamics in salivary glands. Dynamic PAI with co-registered ultrasound (US) was performed in mice to monitor salivary gland hemodynamics in response to exogenous muscarinic receptor stimulation (pilocarpine) and blockade (atropine). Pilocarpine increased salivary gland oxygen saturation (%sO2) within minutes after administration, which was abrogated by atropine. A significant correlation was observed between change in %sO2 measured by PAI and saliva secretion. PAI is a novel imaging method that can be used for functional assessment of neurovascular dynamics in salivary glands. |
| Keywords: | Corresponding author Roswell Park Comprehensive Cancer Center Center for Oral Oncology Elm & Carlton Streets Buffalo NY 14263 USA Fax: +1-716-845-3118 Salivary glands Ultrasonography Pilocarpine Atropine |
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