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Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis |
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| Authors: | Jean-Frédéric Colombel Omoniyi J Adedokun Christopher Gasink Long-Long Gao Freddy J Cornillie Geert R D&#x;Haens Paul J Rutgeerts Walter Reinisch William J Sandborn Stephen B Hanauer |
| Institution: | 1. Department of Gastroenterology, Icahn School of Medicine, Mount Sinai Medical Center, New York, New York;3. Janssen Research & Development, Spring House, Pennsylvania;4. Janssen Scientific Affairs, Horsham, Pennsylvania;6. MSD International, Kriens, Switzerland;5. Department of Gastroenterology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands;7. Universitätsklinik für Innere Medizin III, Vienna, Austria;12. Division of Gastroenterology and Department of Medicine, University of California, San Diego, San Diego, California;8. Department of Medicine, Digestive Health Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois |
| Abstract: | |
| Keywords: | SONIC Exposure-Response Serum Infliximab Concentrations Corticosteroid-Free Clinical Remission Mucosal Healing ADA anti-drug antibody AZA azathioprine CD Crohn’s disease CDAI Crohn's Disease Activity Index CRP C-reactive protein CSFR corticosteroid-free remission rate MH mucosal healing Q quartile SIC serum infliximab concentration TNF tumor necrosis factor |
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