| 青岛地区结核分枝杆菌embB306基因突变特征与乙胺丁醇耐药的关系 |
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| 引用本文： | 郝建玲,邹悦. 青岛地区结核分枝杆菌embB306基因突变特征与乙胺丁醇耐药的关系[J]. 临床荟萃, 2015, 30(1): 41-43,47 |
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| 作者姓名： | 郝建玲 邹悦 |
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| 作者单位： | 青岛市胸科医院 胸三科,山东 青岛,266043 |
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| 摘 要： | 目的：探讨青岛地区结核分枝杆菌 embB306突变特征与乙胺丁醇耐药的关系。方法应用聚合酶链反应（PCR）-DNA 测序法对来自青岛地区36株乙胺丁醇耐药和48株乙胺丁醇敏感的结核分枝杆菌的 embB 基因片段进行分析。结果48株乙胺丁醇敏感菌株中均未发生 embB306突变，而36株乙胺丁醇耐药菌株中有20株发生了embB306突变，突变率为55．6％；embB306突变在乙胺丁醇敏感菌株和乙胺丁醇耐药菌株中的分布差异具有统计学意义（χ2＝35．000，P ＜0．01）。结论在青岛地区，embB306的突变是青岛地区结核分枝杆菌对乙胺丁醇耐药的主要机制。
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| 关 键 词： | 肺纤维化 肺气肿 体征和症状 预后 |
Relationship between ethambutol-resistance and mutations in embB306 gene of mycobacterium tuberculosis in Qingdao area |
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| Hao Jianling,Zou Yue. Relationship between ethambutol-resistance and mutations in embB306 gene of mycobacterium tuberculosis in Qingdao area[J]. Clinical Focus, 2015, 30(1): 41-43,47 |
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| Authors: | Hao Jianling Zou Yue |
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| Affiliation: | Hao Jianling;Zou Yue;Third Department of Tuberculosis,Chest Hospital of Qingdao; |
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| Abstract: | ABSTRACT:Objective To investigate the relationship between ethambutol(EMB)-resistance and mutations in embB306 gene of Mycobacterium tuberculosis in Qingdao area.Methods PCR-direct sequencing technique was used to analyze embB gene of 84 Mycobacterium tub |
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| Keywords: | tuberculosis mycobacterium tuberculosis ethambutol mutation |
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