自由基代谢与精神分裂症临床症状和药物治疗的关系

目的：探讨自由基代谢与精神分裂症临床症状和药物治疗的关系。方法：是否治疗的慢性精神分裂症患者各４０例分别评定定阳性和阴性症状量表（ＰＡＮＳＳ），并测定膜脂质过氧化物丙二醛（ＭＤＡ）含量、铜／锌超氧化物歧化酶（Ｇｕ－ＺｎＳＯＤ）和谷胱苷肽过氧化物酶（ＧＳＨ－Ｐｘ）活性。结果：与健康对照组相比，未治疗组患者ＭＤＡ含量和ＧＳＨ－Ｐｘ活性显著增加，治疗组患者无显著改变；而两组患者ＳＯＤ活性显著降低；未治疗

The involvement of free radicals in schizophrenia,and the relationship with clinical symptoms and antipsychotic treatment

Objective:To investigate the involvement of free radicals and the relationship of oxidative stress with clinical symptoms and antipsychotic drug treatment in schizophrenia. Method:A large cohort of medicated (n=40),unmedicated (n=40) chronic patients with schizophrenia were identified and rated on PANSS.The blood was taken for measurement of plasma malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD) in erythrocytes and of glutathione peroxidase (GSH Px) in plasma. Results:Relative to normal controls,unmedicated patients showed significant elevation of both MDA and GSH Px,but patients medicated with antipsychotic drugs had similar levels to controls;both patient groups showed significant reduction in SOD.In unmedicated patients,MDA levels were reqatively correlated with SOD activity,MDA levels and GSH Px activity were correlated positively with the negative symptom cluster.Increased level of plasma MDA was significantly inversely correlated with decreased RBC SOD activity. Conclusion:Unmedicated chronic schizophrenic patients show evidence of increased oxidative stress,which may aggravate the development of negative symptoms.This has implications for the pathology and antioxidant adjunctive treatment of schizophrenia.Some antipsychotic drugs may act as antioxidants to protect against free radical mediated cellular damage in schizophrenia.