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| 弥漫型非霍奇金淋巴瘤染色体异常与临床预后相关性探讨 | |
| 引用本文： | 汪惠园,程华枫,勇威本,丘镜滢,初雪梅,汪渊. 弥漫型非霍奇金淋巴瘤染色体异常与临床预后相关性探讨[J]. 中国肿瘤临床, 2000, 27(11): 815-817 |
| 作者姓名： | 汪惠园 程华枫 勇威本 丘镜滢 初雪梅 汪渊 |
| 作者单位： | 1. 安徽医科大学附属医院血液科 (合肥市 230022) 2. 淮北杨庄矿职工医院内科 3. 北京大学临床肿瘤学院内科 4. 北京大学人民医院血研所 |
| 基金项目： | 本文课题受安徽省教委自然科学研究基金资助(JL-96-077) |
| 摘 要： | 目的：探讨弥漫型非霍奇金淋巴瘤（ＮＨＬ）染色体异常与临床预后间关系。方法：采用短期培养，Ｇ显带方法对４６例弥漫型ＮＨＬ的淋巴结活检标本进行染色体型分析并与临床结果进行联系。结果：６ｑ２１－２５断裂，３＾＋分别与短的中位生存期和高度恶性ＮＨＬ相关。结论：弥漫型ＮＨＬ染色体异常与临床结果间有相关性。 |
| 关 键 词： | 非霍奇金淋巴瘤 染色体异常 预后 NHL |
| 修稿时间： | 2000-06-12 |
Correlative Study of Chromosomal Abnormality in Non-Hodgkin's Lymphoma and Its Prognosis |
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| Wang Huiyuan, Yong Weiben, Qu Jingying. Correlative Study of Chromosomal Abnormality in Non-Hodgkin's Lymphoma and Its Prognosis[J]. Chinese Journal of Clinical Oncology, 2000, 27(11): 815-817 | |
| Authors: | Wang Huiyuan Yong Weiben Qu Jingying |
| Affiliation: | Wang Huiyuan, Yong Weiben, Qu Jingying Department of Hematology,Affiliated Hospital of Anhui Medical University,Hefei |
| Abstract: | Objective: To study the relationship between chromosomal abnormality of non- Hodgkin's lymphoma (NHL) and its prognosis. Methods: Forty - six lymph node specimens of NHL were cultured in 24 hours and analysed by G banding method. The result was associated with the clinical prognosis of the patients. Results and Conclusion: The mainly chromosomal abnormalities: breaks at 14q - 32. 18q21 .6q21 - 25; structural abnormalities of chromosome 17; trisomy3 .5 . 18 found in study, The results showed that the break of 6q21 - 25 and 3 were correlated with the shortened median survival period and highly malignant NHL respectively. |
| Keywords: | Non- Hodgkin's lymphoma Prognosis Chromosomal abnormality |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |