高场强MRI对不同孕龄胎儿标本脑组织的显示能力研究

目的 探讨高场强MRI对不同孕龄胎儿标本脑组织的显示能力.方法 108个14～40周胎儿标本进行3.0 T MR扫描,并从中选取扫描图像清晰的11个14～27周标本行7.0 T MR扫描.选取不同场强与方位的MR图像,分析MRI对发育中的皮质脑沟、层状结构及基底核团的显示情况.结果 在3.0 T MR胎儿标本T_1WI上,14周时皮质层状结构即可显示;16周后脑沟可以较准确辨认;20周后基底核团可以较清晰辨认,三者都随孕龄增大而逐渐清晰.相同胎龄的胎儿标本在7.0 T MR T_2WI上,脑沟、层状结构及基底核团的显示较3.0 T T_1WI图像更加清楚,尤其优于显示发育早期阶段的脑沟.结论 3.0 T MR胎儿标本T_1WI可以较好地显示发育中的胎脑结构;7.0 T MR T_2WI可以更加清晰地显示皮质脑沟、层状结构与基底核团的发育变化.

The capability of high field MRI in demonstrating post-mortem fetal brains at different gestational age

Objective To study the capability of high field MRI in demonstrating the post-mortem fetal brains at different gestational age(GA).Methods One hundred and eight post-mortem fetal brains of 14-40 weeks GA were evaluated by 3.0 T MRI. Eleven brains of 14 to 27 weeks GA with good 3.0 T MRI images were chosen and scanned by 7.0 T MRI. The developing sulci, layered structures of fetal cerebral cortex and basal nuclei were evaluated on MRI of different Tesla(3.0 T and 7.0 T)and their results analyzed. Results On T_1 WI of 3.0 T MRI, the layered structures of fetal cerebral cortex were present at 14 weeks GA, the sulci were more accurately identified after 16 weeks GA. The basal nuclei were clearly distinguishable after 20 weeks GA. and these structures were better visualized as the GA increased. On T_2WI of 7.0 T MRI, the sulei, layered structures of fetal cerebral cortex and basal nuclei were shown more clearly at the same GA when compared to 3.0 T, especially the sulci at the early developmental stages. Conclusions T_1 WI of 3.0 T MRI could show the developing structures of post-mortem fetal brain well, but the T_2 WI of 7.0 T MRI were comparatively better.