PPARγ基因多态性与精神分裂症的关系

目的：在中国北方汉族人群中探讨过氧化物酶体增殖体激活受体γ（PPARγ）基因多态性与精神分裂症的关系，分析PPARγ基因多态性与精神分裂症的关系。方法：采用PCR技术和限制性内切酶片段长度多态性（RFLP）的方法，检测中国北方汉族111个核心家系，共333个研究对象的PPARγ基因的等位基因和基因型。结果：PPARγ基因的2个SNPs（rs2972162和rs2938395）的基因型和等位基因在病例组和对照组的频数分布差异均无显著性（P>0.05）；传递不平衡检验表明，2个SNP与精神分裂症不存在关联性（P>0.05）；2个SNPs单倍型与精神分裂症无关联（P>0.05）。结论：在中国北方汉族人群中PPARγ基因多态性与精神分裂症的发病可能无关联。

Association between PPARγ gene polymorphism and schizophrenia

Objective To investigate the genentic association between the peroxisome proliferators-activated receptor γ(PPARγ) gene polymorphism and schizophrenia in the Han descent population in the north of China.Methods A PCR-based RFLP procedure was employed to detect the alleles and genotypes of PPARγ gene in 111family trios including 333 subjects of Han descent population in the north of China.Results No significant difference was found in the frequencies of genotypes and alleles of the two SNPs(rs2972162 and rs2938395) of PPARγ gene between case group and control group.The TDT analysis result showed that the two SNPs were not associated with schizophrenia.The 2-SNP haplotype was not associated with schizophrenia.Conclusion There is no genentic association between the PPARγ gene polymorphism and schizophrenia in the Han descent population in the north of China.