Lymphocyte stimulation by acetylcholine receptor in polymyositis |
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Authors: | B. M. Conti-Tronconi M. Morgutti M. G. Albizzati F. Clementi |
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Affiliation: | (1) Departments of Pharmacology and Neurology of the University of Milan, Italy;(2) CNR Center of Cytopharmacology, 20129 Milano, Italy |
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Abstract: | Summary Lymphocytes of twenty-seven patients with polymyositis were incubated in vitro with cholinergic receptor rich membranes obtained from the electric organs of Torpedo Marmorata.Lymphocytes of polymyositic patients were slightly stimulated; positive responses were present mainly in patients affected from more than a year. Sensitization against the nicotinic cholinergic receptor may explain the occurrence of the myasthenic syndrome with polymyositis.Fellow of the A. Villa Rusconi foundation |
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Keywords: | Polymyositis Myasthenia gravis Acetylcholine receptor Lymphocyte stimulation |
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