组织工程血管移植在血液透析通路中的应用

目的:探讨组织工程血管移植应用于血液透析(HD)通路的可行性。方法:广泛查阅近期有关组织工程血管应用于HD通路的文献,对其动物模型及临床研究进行总结评价。结果:分层构建法可获得具有足够机械强度的组织工程血管。此后出现的简化分层构建组织工程血管在一系列动物模型及临床实验中被证明可用于动静脉通路的建立。近期一种生物反应器构建组织工程血管在狒狒模型上进行动静脉搭桥试验也获得成功,有望成为较理想的动静脉内瘘移植血管。结论:组织工程血管移植应用于HD通路是可行的,值得进一步研究。

Application of tissue-engineered blood vascular as hemodialysis access

Objective:To discuss the feasibility of tissue-engineered blood vascular(TEBV) as hemodialysis access.Methodology:The recent literatures about TEBV as arteriovenous access for hemodialysis were widely reviewed.Animal and clinical studies were summarized and evaluated.Results:Vascular graft with sufficient mechanical properties can be built by sheet-based tissue engineering and effectiveness of grafts by simplified sheet-based tissue engineering were testified in a series of animal and clinical studies as arteriovenous access.Recently,a kind of TEBV grafts cultured in a bioreactor that delivers cyclic radial strain were tested in a baboon model as competent arterial bypass and may provide a readily available option for hemodialysis.Conclusion:It is feasible to use TEBV grafts to build hemodialysis access and worth of further study.