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| Muscarinic stimulation rescues β_1-adrenergic response in transgenic mouse heart overexpressing β_2-adrenoceptor | |
| 作者姓名： | ZHANG Shengjun CHENG Heping ZHOU Yingying WANG Dingji Bruce Ziman Harold Spurgoen Robert J.Lefkowitz Edward G.Lakatta Walter J.Koch XIAO Ruiping Laboratory of Cardiovascular Sciences Gerontology Research Center National Institute on Aging Baltimore Maryland Dept.of Medicine and Howard Hughes Medical Institute Duke University Medical Center Durham NC Dept.of Surgeon Duke University Medical Center Durham NC |
| 作者单位： | ZHANG Shengjun 1)，CHENG Heping 1)，ZHOU Yingying 1)，WANG Dingji 1)，Bruce Ziman 1)，Harold Spurgoen 1)，Robert J.Lefkowitz 2)，Edward G.Lakatta 1)，Walter J.Koch 3)，XIAO Ruiping 1) 1)Laboratory of Cardiovascular Sciences，Gerontology Research Center，National Institute on Aging，Baltimore，Maryland 21224 2)Dept.of Medicine and Howard Hughes Medical Institute，Duke University Medical Center，Durham，NC 3)Dept.of Surgeon，Duke University Medical Center，Durham，NC |
| 摘 要： | ＩＮＴＲＯＤＵＣＴＩＯＮＩｎａｄｄｉｔｉｏｎｔｏｔｒａｄｉｔｉｏｎａｌｐｈａｒｍａｃｏｌｏｇｉｃａｌａｐｐｒｏａｃｈ ｅｓ ,ｍｏｕｓｅｇｅｎｏｍｉｃｍａｎｉｐｕｌａｔｉｏｎｈａｓｏｐｅｎｅｄｎｅｗａｖｅｎｕｅｓｔｏｉｎｖｅｓｔｉｇａｔｉｏｎｏｆｔｒａｎｓｍｅｍｂｒａｎｅｓｉｇｎａｌｔｒａｎｓｄｕｃｔｉｏｎ ,ｐａｒ ｔｉｃｕｌａｒｌｙｔｈｏｓｅｍｅｄｉａｔｅｄｂｙＧｐｒｏｔｅｉｎ ｃｏｕｐｌｅｄｒｅｃｅｐｔｏｒｓ .Ｏｗｉｎｇｔｏｔｈｅｃｒｉｔｉｃａｌｒｏｌｅｏｆβ ａｄｒｅｎｅｒｇｉｃｒｅｃｅｐｔｏｒ… |
| 关 键 词： | β-adrenergic receptor subtypes muscarinic receptor receptor desensitization β-adrenergic receptor kinases inhibitory G proteins cardiac myocytes |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |