氧化LDL抗体对颈动脉粥样硬化斑块发生影响

目的 探讨氧化低密度脂蛋白抗体(oxLDL-Ab)在颈动脉粥样硬化斑块发生中的作用.方法 通过颈动脉超声检查确诊存在颈动脉粥样硬化斑块的患者60例,对照143例.采用酶联免疫吸附实验(ELISA法)测定ox-LDL-Ab水平,同时测定血压、血脂、体质指数(BMI)等可能的影响因素.结果 病例组oxLDL-Ab含量为(15.4±8.8)U/ml,低于对照组的(32.3±20.4)U/ml.控制各种可能的混杂因素后,oxLDL-Ab仍然与颈动脉粥样硬化斑块的发生有关(P=0.001,OR=0.919,95%CI=0.876～0.965).结论 oxLDL-Ab在颈动脉粥样硬化斑块的发生中可能具有保护作用.

Relationship between antibodies against oxLDL and occurrence of carotid atherosclerosis plaques

Objective To investigate the role of antibod ies against oxidized low-density lipop rotein(oxLDL -Ab)in the occurrence of a the roscle rosis plaques.Methods A case-control study was conducted.Sixty cases with a the roscle ros is plaques were diagnosed through carotidultrasonog raphy examination.One hund red and forty three normal subjects were chosen as the control group.The levels of oxLDL-Ab were determined by enzyme linked immunosorbentassay(EL ISA).Blood lipids and BMI were also measured for multivariate analysis.Results The concentration of oxLDL-Ab was 15.4±8.8 U/ml in the patients,while it was 32.3±20.4 U/ml in the control group.The level of oxLDL-Ab in the patients was significantly lower than that of in the control group.The level of oxLDL-Ab was negatively correlated with atherosclerosis plaques after controlling confounding factors(P=0.001,OR=0.919,95% CI:0.876～0.965).Conclusion The antibodies against oxLDL may play a protective role in the occurrence of a the roscle rosis plaques.