良性与恶性疾病胃粘膜活检标本核仁组成区嗜银蛋白的研究

本文采用嗜银染色技术研究正常、炎症和不典型增生胃粘膜以及胃癌和癌旁粘膜（距癌１ｃｍ内）组织核仁组成区嗜银蛋白（ＡｇＮＯＲ）的变化。结果表明，轻、中、重度不典型增生组织ＡｇＮＯＲ数量相差显著（Ｐ＜０．０５或０．０１），胃癌组织ＡｇＮＯＲ数量高于胃良性病变，不同分化程度的癌组织ＡｇＮＯＲ计数无统计学差异，癌旁组织与正常、炎症胃粘膜组织ＡｇＮＯＲ计数无差异。作者认为，ＡｇＮＯＲ计数有助于鉴别胃良、恶性组织，提高胃镜活检小组织病理诊断的正确率，ＡｇＮＯＲ与肿瘤组织分化程度无关。

Study On Nucleolar Organizer Regions in Bioptic Samples of Benign and Malignant Gastric Mucosa

The changes of argentaffin protein in nucleolar organizer regions (AgNOR) in normal, inflammatory,atypical prolification of gastric mucosa, gastric cancer,and surrounding mucosa of cancer (within 1cm area of cancer) were studied with the argentaffin protein staining technique. The results showed that the AgNOR counts were different in various degree prolification tissues (P<0.05 or 0.01). The count of AgNOR in gastric cancer tissue was higher than that of benign gastric tissues, and there was no changes of the AgNOR count in various differentiation cancer tissue. The AgNOR count in tissues around cancer and normal, inflammatory gastric mucosa did not change much. As a result, the AgNOR count was helpful to indentify malignant and benign gastric diseases and AgNOR had no relationship with the degree of differentiation in tumor tissue.