| 异丁司特药代动力学的研究 |
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| 引用本文： | 曾凡波,崔小瑞,周漠炯,熊友玲,张华锋,王涛,刘纪寿.异丁司特药代动力学的研究[J].华中科技大学学报(医学版),2000,29(3). |
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| 作者姓名： | 曾凡波 崔小瑞 周漠炯 熊友玲 张华锋 王涛 刘纪寿 |
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| 作者单位： | 1. 同济医科大学药学院药物研究室,武汉,430030
2. 广东珠海丽珠集团药物研究所,珠海,529020 |
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| 摘 要： | 应用高效液相色谱分离测定的方法 ,研究了犬口服异丁司特的药代动力学。回收率参数 >95 % ,检测灵敏度为 1ng/ ml,变异系数 <5 % ,口服异丁司特后吸收迅速 ,2 4h内基本消除 ,应用 AIC法对异丁司特的血药浓度 -时间曲线拟合 ,口服后在犬体内药代动力学过程符合一室模型
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| 关 键 词： | 异丁司特 药代动力学 色谱法 高效液相 |
Pharmacokinetic Studies of Ibudlast in Dogs |
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| Zeng Fanbo,Cui Xiaorui,Zhou Mojiong Drug Research Institute,School of Pharmacy,Tongji Medical University,Wuhan.Pharmacokinetic Studies of Ibudlast in Dogs[J].Journal of Huazhong University of Science and Technology(Health Sciences),2000,29(3). |
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| Authors: | Zeng Fanbo Cui Xiaorui Zhou Mojiong Drug Research Institute School of Pharmacy Tongji Medical University Wuhan |
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| Institution: | Zeng Fanbo,Cui Xiaorui,Zhou Mojiong Drug Research Institute,School of Pharmacy,Tongji Medical University,Wuhan 430030 |
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| Abstract: | By using high performance liquid chromatography (HPLC), the pharmacokinetics was studied in dogs after oral feeding Ibudlast. The mean recoveries of Ibudlast were more than 95 %, the sensitivity was 1 ng/ml and the coefficient of variation was less than 5 %. After oral administration, Ibudlast was quickly absorbed and almost all of it was eliminated within 24 h. The blood concentration time cure for Ibudlast was adequately fitted to one compartment model. |
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| Keywords: | Ibudlast pharmacokinetics chromatography |
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