| 头孢曲松钠的电化学行为研究及伏安法测定 |
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| 引用本文： | 胡延维,屠一锋. 头孢曲松钠的电化学行为研究及伏安法测定[J]. 抗感染药学, 2005, 2(4): 148-149 |
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| 作者姓名： | 胡延维 屠一锋 |
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| 作者单位： | 1. 苏州大学药学院,江苏,苏州,215007
2. 苏州大学化学化工学院,江苏,苏州,215006 |
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| 摘 要： | 目的:研究头孢曲松钠的电化学行为。方法:用线性扫描、循环伏安及微分脉冲极谱等多种电化学手段进行测定。结果:在pH为5.0的NaAc-HAc溶液中，头孢曲松钠(ceftriaxone，简称CTRX)有两个灵敏的伏安峰，峰电流与头孢曲松钠的浓度在4.0×10~(-7)5.0×10~(-6)mol/L范围内成线性关系。用于注射剂的测定，得到满意的结果。结论:实验表明其中一个峰属于有吸附性的不可逆过程，另一为非吸附性的可逆过程，测得电极反应的电子转移数n=2。
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| 关 键 词： | 头孢曲松钠 电化学行为 循环伏安 微分脉冲极谱法 |
| 文章编号： | 1672-7878（2005）04-0148-02 |
| 收稿时间： | 2005-04-26 |
| 修稿时间： | 2005-04-26 |
Electrochemical Behaviour and Determination by Voltammetry of Ceftriaxone |
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| HU Yan-wei,TU Yi-feng. Electrochemical Behaviour and Determination by Voltammetry of Ceftriaxone[J]. Anti-infection Pharmacy, 2005, 2(4): 148-149 |
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| Authors: | HU Yan-wei TU Yi-feng |
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| Affiliation: | HUYan-wei~1,TU Yi-feng~2 |
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| Abstract: | Objective:To search for the electrochemical behaviour of ceftriaxone.Methods:To determine by Voltammetry. Results:In NaAc-HAc solution pH 5.0,two sensitive peaks of ceftriaxone(CTRX) were observed.The linear relationship between peak height and the concentration of CTRX held in the rang of 4.0×10~(-7)～5.0×10~(-6)mol/L.This mothod has been successfully used to determine ceftriaxone in injection.The electrochemical behaviour of ceftriaxone was also studied by linear sweep, cyclic voltammetry. Conclusion: It has been shown that one of the peaks is an irreversible adsorption wave, the other one is a reversible reductive wave.The number of electron transfer has been determined to be two. |
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| Keywords: | Ceftriaxone electrochemical behaviour cyclic voltammetry differential pulse voltammetry |
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