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Effect of platelet activity of inhibition of adenylate cyclase |
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| Authors: | EW Salzman DE MacIntyre ML Steer JL Gordon |
| Institution: | a Department of Surgery, Harvard Medical School and Beth Israel Hospital, Boston, Ma., U.S.A. b A.R.C. Institute of Animal Physiology, Babraham, and University Department of Pathology, Cambridge, England |
| Abstract: | SQ22536 (9-tetrahydro-2-furyl]-adenine), an inhibitor of adenylate cyclase, blocks the inhibition of platelet function by substances that stimulate this enzyme, including PGE1, PGI2, PGD2, and adenosine. SQ22536 enhances platelet aggregation and serotonin release induced by prostaglandin endoperoxides and their analogs but does not consistently affect the platelet response to ADP or other agonists. SQ22536 reduced platelet cyclic AMP and inhibits the effect on this nucleotide of PGE1 and adenosine. The elevation of cyclic GMP induced by ADP is prevented by SQ22536. |
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