大连地区2型糖尿病危险因素的非条件Logistic回归分析

背景糖尿病是环境因素、遗传因素等多种因素所导致的慢性全身性代谢疾病,其病因仍不十分清楚.探讨上述危险因素在糖尿病发病中的作用,对制定糖尿病的一、二级预防措施有重要意义.目的探讨2型糖尿病危险因素,为制定适宜的干预措施提供依据.设计以诊断为依据的横断面研究.单位一所大学的流行病学教研室、一所大学医院的内分泌科.对象采取分层、整群的随机抽样方法,在大连城乡居住5年以上、年龄在40岁以上的常住居民中,按城市和乡村分两层,每层抽取1250人,两层共抽取2 500人.被抽中的原糖尿病患者亦予以统计.方法问卷调查,同时进行身高、体质量、腰围、臀围、血压及血糖等项目的体检.以2型糖尿病患者做为病例组,正常人做为对照组,采用单因素及多因素非条件Logistic回归分析方法进行分析.主要观察指标与2型糖尿病发病相关因素的单因素及多因素非条件Logistic回归分析.结果糖尿病家族史(OR=2.339)、肥胖(体质量指数,OR=1.462)、收缩压升高(OR=1.016)、高血脂(OR=1.615)、年龄(OR=1.043)是2型糖尿病的主要危险因素.结论糖尿病家族史、收缩压升高、肥胖、高血脂及年龄是2型糖尿病的危险因素,对高危人群及全人群采取措施适当控制体质量、血压等是预防该病发生的重要手段.

Unconditional logisticregression analysis of risk factors of type 2 diabetes mellitus in Dalian

BACKGROUND: Diabetes mellitus is a chronic metabolic disease caused by various factors,such as environmental factor,inherited factor,etc.,and its cause isn't very clear now. This study aims to investigate the risk factors mentioned above in the onset of diabetes mellitus, and is of significance in the first and second grade of prevention of diabetes mellitus.OBJECTIVE: To investigate the risk factors of type 2 diabetes mellitus to provide evidence for the proper intervention of it.DESIGN: Cross-sectional study based on diagnosis.SETTING: Department of epidemiology in a university and department of endocrinology in a university hospital.PARTICIPANTS: The subjects were residents who have resided in town and country of Dalian for more than 5 years and were elder than 40 years old. The method of stratified cluster random sampling was carried out among natural persons who were divided into two groups according to city and country. Totally 2 500 persons were taken in total and 1 250 persons were from each group. The subjects who had been diagnosed as diabetes mellitus were included.METHODS: Questionnaire survey was employed for all the subjects, including physical examinations such as height,weight,waist girth,hip girth,blood pressure,blood glucose,etc. Patients of type 2 diabetes mellitus were taken as the case group and the normal was as the control group. The unconditional univariate and multivariate logistic regression were used.MAIN OUTCOME MEASURES: Unconditional logistic regression analysis of risk factors of type 2 diabetes mellitus with single factor analysis and multivariate analysis.RESULTS: Family history of diabetes mellitus(OR = 2.339),obesity[body mass index(BMI),OR = 1.462],systolic pressure(OR = 1.016),hyperlipidemia(OR = 1.615), age(OR = 1.043) were the major risk factors for type 2 diabetes mellitus.CONCLUSION: Family history of diabetes mellitus, increase of systolic pressure,obesity,high blood lipid and age are the risk factor for type 2 diabetes mellitus. For all communities,control of body mass and high blood pressure is an important way to prevent type 2 diabetes mellitus.