对慢性HB患者血清中HBsAg特异性循环免疫复合物、类风湿因子、免疫胶固素的综合观察

在不同病型的慢性HB患者中检测HAsAg特异性CIC、RF和IK,发现HBAC、CAH的RF和IK检出率显著高于CPH,与HBsAg-CIC在不同病型间检出率的差别相一致。此外,HBAC、CAH与CPH比较,RF、IK伴随HBsAg-CIC同时检出的频率高而且持续时间也长。在动态观察中发现HBsAg-CIC、RF、IK以及血清中可溶性CIC补体消耗的水平有一致性改变,并且与活动性肝功能损害的加重有密切关系,指出RF、IK可能是慢性HBV感染中对宿主有害的致病因素。

A Comprehensive Observation on HBsAg--specific Serum CIC, RF, IK in Patients with Chronic HB

Parallel detections of RF, IK and HBsAg-specific CIC were performed in different types of patients with chronic HB. Our study disclosed that the incidence of RF, IK in HBAC and CAH was remarkably higher than that in CPH, and this result was consistent with the difference of the incidence of HBsAg-CIC among these types of disease. In addition, in HBAC and CAH the incidence of RF and IK clo-sely followed by HBsAg-CIC was higher and their keeping time was also longer than those in CPH. Dynamic observations showed that there existed a consistent changes among HBsAg-CIC, RF, and the level of the comple. mentconsumed by soluble CIC in patient's sera, and a close relationship with the aggravation of hepatic func-tion impairment. The data suggested that RF and IK might be harmful pathogenetic factors to the host in chronic HBV infection.