辅酶Q10与供心缺血再灌注损伤 |
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引用本文: | 巫国勇,钟佛添.辅酶Q10与供心缺血再灌注损伤[J].广东医学,1998,19(9):648-649. |
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作者姓名: | 巫国勇 钟佛添 |
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作者单位: | 中山医科大学附属第一医院心胸外科!510080 |
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摘 要: | 目的:探讨Co-Q10与供心血缺血再灌注损伤的关系,评价Co-Q10对供心缺血再灌注损伤的保护作用。方法:选用16只新西兰大白兔随机分为对照组和实验组。常规取心后用UW液冷保存6小时;然后在Langendorff模型上,对照组用KHB液灌注,实验组用KHB+Co-Q10液灌注30分钟。分别测定灌注前、后的心肌丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性。结果:实验组MDA含量明显低于对照组(
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关 键 词: | 辅助酶Q10 再灌注损伤 心肌缺血 |
Coenzyme Q_(10) and Ischemia-reperfusion Injury of Donor Heart |
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Abstract: | Objective: This study is to investigate the relation of Co-Q10 and ischemia reperfusion injury of donor heart;and valus the protective effect of Co-Q10 on ischemia reperfusion injury of donor heart.Mehtods: New-Zealand Rabbits (n =16) were divided into two groups:control group as group 1, expenmental group as group 2. After hearts were isolated,preservation in UW fluid for six hours was given.Furthermore,on Langendorff model, hearts in group 1 were reperfused with KHB fluid while hearts in group 2 with KHB+ Co- Q10 fluid for 30 minutes. The MDA MDA and SOD were determined before reperfusion and at the end of reperfusion. Results: The MDA in group 2 was lower than group 1, but the SOD was higher in group 2 (P<0.05).Conclusions: Co- Q10 has an obvious protective effect on ischemia-reperfusion injury of donor heart. |
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Keywords: | Co-Q_(10) Ischemia-reperfusion injury Experimental study |
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