血管内皮生长因子、环氧化酶-2在急性白血病中的表达及其与血管新生的关系

目的探讨血管内皮生长因子（VEGF）、环氧化酶-2（COX-2）在急性白血病（AL）的表达及与血管新生的关系。方法应用酶联免疫吸附试验（EHSA）测定23例AL初发未治，21例完全缓解（CR），18例复发患者血清中VEGF、COX-2的含量，并与正常对照组比较。结果AL初发未治组、复发组患者血清VEGF、COX-2的含量明显高于正常对照组，差异有统计学意义（P〈0．01）；CR组患者血清VEGF、COX-2的含量较初发未治组明显下降，与正常对照组比较，差异无统计学意义（P〉0．05）；复发组血清VEGF、COX-2的含量明显高于CR组，差异有统计学意义（P〈0．01）。结论VEGF、COX-2与AL的发生、发展密切相关，COX-2可能通过上调VEGF促进AL的血管新生及发生、发展，抗VEGF和COX-2有望成为白血病治疗新的靶点。

Expression of VEGF and COX-2 and their relationship with angiogenesis in acute leukemia

Objective To investigate the expression of vascular endothelial growth factor （VEGF）, cyclooxygenase-2 （COX-2） in acute leukemia and its relationship with angiogenesis. Methods Serum levels of VEGF, COX-2 in 23 primary untreated patients, 21 complete remission （CR） , 18 relapsed patients with AL were measured by enzyme-linked immunosorbent assay （ ELISA ） , and compared with that of nomal controls. Result Serum levels of VEGF,COX-2 in primary untreated patients,relapsed patients were significantly higher than nomal controls （P 〈 0. 01 ）. Serum levels of VEGF, COX-2 in C R patients decreased significantly, showing no significant difference from those of nomal controls（ P 〉 O. 05 ）. In relapsed patients,Serum levels of VEGF,COX-2 were higher obviously than in CR patients （P 〈 0.01 ）. Conclusion The expressions of VEGF, COX-2 are closely correlated in acute leukemia, COX -2 may regulate VEGF expression,and promote angiogenesis and acute leukemia development. Preventing expressions of VEGF,COX-2 may be as targets in the leukemia therapy in the future.