| 月经生育因素与乳腺癌关系的Meta分析 |
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| 引用本文： | 张俊清,吴艳乔,张敏,陈春蓉. 月经生育因素与乳腺癌关系的Meta分析[J]. 现代预防医学, 2010, 37(7) |
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| 作者姓名： | 张俊清 吴艳乔 张敏 陈春蓉 |
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| 作者单位： | 四川大学华西公共卫生学院卫生统计教研室,成都,060041 |
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| 摘 要： | [目的]运用Meta分析方法综合分析评价月经生育因素与中国女性乳腺癌的关系。[方法]收集国内有关乳腺癌月经生育因素的病例对照研究文献22篇,采用可信区间方差分析法计算各相关因素的ORc及95%CI。[结果]各研究因素的ORc及95%CI分别为:初潮年龄ORc=0.540(0.450～0.648)、结婚年龄1.376(0.815～2.322)、初产年龄1.558(1.253～1.937)、生育与否0.718(0.320～1.616)、生育胎数0.97(0.705～1.335)、哺乳0.391(0.253～0.605)、哺乳时间0.94(0.884～0.999)、人工流产1.844(1.442～2.358)、绝经与否1.869(1.014～3.444)、绝经年龄1.034(0.706～1.515)、行经期1.223(1.034～1.446)、月经紊乱3.217(2.278～4.542)、月经周期0.446(0.372～0.535)、口服避孕药1.400(0.977～2.006)。[讨论]初潮年龄、哺乳和哺乳时间是乳腺癌的保护因素,初产年龄、人工流产、绝经及行经期是乳腺癌的危险因素,结婚年龄、生育、生育胎数、绝经年龄、月经紊乱、月经周期和口服避孕药与乳腺癌关系尚不明确,有待进一步研究。
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| 关 键 词： | 乳腺肿瘤 月经生育因素 Meta分析 |
RELATIONSHIP BETWEEN MENSTRUAL AND REPRODUCTIVE FACTORS AND FEMALE BREAST CANCER IN CHINA:META-ANALYSIS |
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| ZHANG Jun-qing,WU Yan-qiao,ZHANG Min,et al.. RELATIONSHIP BETWEEN MENSTRUAL AND REPRODUCTIVE FACTORS AND FEMALE BREAST CANCER IN CHINA:META-ANALYSIS[J]. Modern Preventive Medicine, 2010, 37(7) |
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| Authors: | ZHANG Jun-qing WU Yan-qiao ZHANG Min et al. |
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| Affiliation: | ZHANG Jun-qing,WU Yan-qiao,ZHANG Min,et al.(West China School of Public Health,Sichuan University,Chengdu 610041,China) |
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| Abstract: | [Objective] To study the relationship between breast cancer and menstrual and reproductive factors in China with Meta analysis.[Methods] The results from 22 literatures about case-control studies on menstrual and reproductive factors of breast cancer were analyzed quantitatively and synthetically by meta-analysis,ORc and 95%CI were computed.[Results] Respectively the pooled odds ratio value of each factor was:age at menarche(y) OR=0.540(0.450-0.648),marriage age 1.376(0.815-2.322),primiparous age 1.558(1.25... |
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| Keywords: | Breast cancer Menstrual and reproductive factors Meta-analysis |
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