The photopic negative response of flash ERG in nonproliferative diabetic retinopathy |
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Authors: | Hongling Chen Mingzhi Zhang Shizhou Huang Dezheng Wu |
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Institution: | (1) Department of Neuro-ophthalmology and Electrophysiology, Narayana Nethralaya, Super Speciality Eye Hospital and Post Graduate Institute of Ophthalmology, 121/C, Chord Road, Rajajinagar, 1st ‘R’ Block, Bangalore, 560 010, India;(2) Department of Vitreo-Retina, Narayana Nethralaya, Super Speciality Eye Hospital and Post Graduate Institute of Ophthalmology, 121/C, Chord Road, Rajajinagar, 1st ‘R’ Block, Bangalore, 560 010, India |
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Abstract: | Purpose To evaluate with electrophysiological responses and Optical Coherence Tomography (OCT), the short term functional and structural
effects at the macula following intravitreal injection of bevacizumab for macular edema. Methods Prospective, non-randomized, interventional case study. In total, 17 eyes of 17 patients with macular edema due to vein occlusions
and diabetic retinopathy received intravitreal bevacizumab. All Patients underwent complete ophthalmic examination including
Snellen visual acuity testing, Multifocal Electroretinography (mfERG) and Full Field Electroretinography (FERG), OCT scanning
at baseline at 1 week and 2 months after intravitreal bevacizumab. Results FERG did not show any change in waveform parameters following intravitreal injection of bevacizumab. Average mfERG macular
responses within central 20° showed increased P1 amplitude (P < 0.05) at 2 months after treatment as compared to the baseline recordings in all subjects. No changes were seen in the implicit
time. There was 22% improvement in central retinal thickness (CRT) at 2 months compared to the baseline (P < 001). Conclusion Intravitreal injection bevacizumab resulted in reduction in the central retinal thickness and mild to moderate improvement
in the mfERG amplitudes in this short-term study. The visual acuity changes did not directly correlate with the reduced central
retinal thickness or improvement in mfERG. The short-term results showed no serious ocular adverse effects. Therefore on short-term
follow up the off label drug showed improvement of macular edema secondary to vein occlusion and diabetic retinopathy with
no demonstrable toxic effects. |
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Keywords: | Bevacizumab Macular edema Electroretinography |
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