卒中后抑郁患者的交感神经皮肤反应

目的探讨卒中后抑郁患者的交感神经皮肤反应（SSR）变化。方法对60例卒中后抑郁患者（PSD）和58例健康对照者分别进行了SSR测定,并将结果加以比较。同时根据Hamilton抑郁量表（HAMD）评分将PSD患者分为轻中度抑郁组（〈24分）和重度抑郁（〉24分）组,比较两组SSR结果。结果卒中后抑郁患者SSR异常率为86.6%（52/60）,PSD患者SSR潜伏期较对照组延长（P〈0.01）,波幅值较对照组降低（P〈0.01）。亚组分析显示重度抑郁组SSR潜伏期以及波幅值较轻中度抑郁组延长和降低,其差异具有显著性（P〈0.01）。结论卒中后抑郁患者交感神经皮肤反应明显异常,同时其异常程度与抑郁严重程度相关,可作为卒中后抑郁患者的诊断参考指标应用于临床。

Sympathetic skin response in patients with post-stroke depression

Objective To investigate the change of sympathetic skin response（SSR） in patients with post-stroke depression（PSD）.Methods 60 patients with post-stroke depression and 58 healthy as controls were measured in SSR.According to Hamilton Depression Rating Scale（HAMD） score,The PSD group was divided into mild to moderate（〈24 points） subgroup and severe depression（〉24 points） subgroup.Results SSR abnormal rate in patients with PSD was 86.6%（52/60）.SSR in PSD patients had longer latency（P〈0.01） and lower amplitude（P〈0.01） than that of control group.A subgroup analysis showed that severe depression subgroup latency was prolonged and amplitude was reduced compared with that of the other subgroup（P〈0.01）.Conclusion It was very clearly that sympathetic skin responses in patients with PSD were dysfunctional.SSR abnormal level was associated with an increased degree of depression..