Expression of membrane-type matrix metalloproteinases in synovial tissue from patients with rheumatoid arthritis or osteoarthritis |
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| Authors: | H Mitsui N Tsuchiya S Okinaga K Matsuta K Yoshimura A Nishimura |
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| Institution: | (1) Department of Orthopedics, Mitsui Memorial Hospital, Tokyo, Japan, JP;(2) Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan, JP;(3) Department of Orthopedics, Kanto Central Hospital, Tokyo, Japan, JP;(4) Matsuta Clinic, Tokyo, Japan, JP;(5) Discovery Research Laboratories II, Pharmaceutical Discovery Research Division, Takeda Chemical Industries Ltd., 10 Wadai, Tsukuba 300-4247, Japan Tel. +81-298-64-6352; Fax +81-298-64-6308 e-mail: Nishimura_Atsushi@takeda.co.jp, JP |
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| Abstract: | We investigated the expression of membrane-type matrix metalloproteinase (MT-MMP) and matrix metalloproteinase (MMP) mRNAs
in synovial tissue from patients with rheumatoid arthritis (RA, n = 5) or osteoarthritis (OA, n = 5) by Northern blot analysis. Northern analysis demonstrated strong expression of MT1-MMP, MT3-MMP, MMP-1, and MMP-3 and
weak expression of MT2-MMP and MMP-8 in synovial tissue from patients with RA or OA. MT4-MMP was not detected. No significant
difference was shown in the expression of MT-MMP mRNAs between RA and OA. Synovial tissue of RA or OA patients expressed MT-MMPs
as well as MMPs. These results indicate that, in addition to MMPs, MT1-MMP, MT3-MMP, and probably MT2-MMP may play a role
in the degradation of bone and cartilage matrix in RA and OA. Such information may provide a clue to the development of a
novel therapeutic approach targeted on the prevention of joint destruction.
Received: April 30, 2000 / Accepted: September 19, 2000 |
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| Keywords: | Matrix metalloproteinases (MMPs) Membrane-type matrix metalloproteinases (MT-MMPs) Osteoarthritis (OA) Rheumatoid arthritis (RA) Synovial tissues |
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