| 塞莱西布诱导胆囊癌细胞凋亡和生长抑制的作用 |
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| 引用本文： | 王玉同,窦科峰. 塞莱西布诱导胆囊癌细胞凋亡和生长抑制的作用[J]. 医学争鸣, 2005, 26(13): 1213-1215 |
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| 作者姓名： | 王玉同 窦科峰 |
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| 作者单位： | 第四军医大学西京医院肝胆外科,陕西,西安,710033;第四军医大学西京医院肝胆外科,陕西,西安,710033 |
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| 摘 要： | 目的:研究塞莱西布对人胆囊癌细胞生长抑制及诱导凋亡的作用.方法:应用TUNEL,MTT法,流式细胞技术等方法对经塞莱西布作用的人胆囊癌细胞进行观察和检测.结果:塞莱西布对人胆囊癌细胞具有明显的生长抑制和促进调亡作用(P<0.05),在一定范围内存在时间依赖关系和剂量依赖关系(P<0.05).结论:塞莱西布诱导肿瘤细胞产生凋亡,是其对肿瘤细胞生长抑制作用的基础.
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| 关 键 词： | 塞莱西布 环氧化酶-2 细胞凋亡 |
| 文章编号： | 1000-2790(2005)13-1213-03 |
| 修稿时间： | 2004-11-20 |
Effect of celecoxib on growth inhibition and induction of apoptosis in gallbladder cancer cells |
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| WANG Yu-Tong,DOU Ke-Feng. Effect of celecoxib on growth inhibition and induction of apoptosis in gallbladder cancer cells[J]. Negative, 2005, 26(13): 1213-1215 |
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| Authors: | WANG Yu-Tong DOU Ke-Feng |
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| Abstract: | AIM: To study the effect of celecoxib, a selective cyclooxygenase-2 inhibitor, on the growth inhibition and the induction of apoptosis in gallbladder cancer cells. METHODS: After the treatment of celecoxib, we used TUNEL, MTT and flow cytometry (FCM) to observe the changes of gallbladder cancer cells. RESULTS: Growth inhibition and typical apoptosis were observed in gallbladder cancer cells after they were treated by celecoxib (P<(0.05)). The growth inhibition was to some extent in a time- and dose-dependent manner(P<0.05). CONCLUSION: Celecoxib can inhibit the growth of gallbladder cancer cells by inducing the apoptosis of these cells. |
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| Keywords: | celecoxib cyclooxygenase-2 apoptosis |
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